ArticleBiomedical reports2019
Detection of oral bacteria on the tongue dorsum using PCR amplification of 16S ribosomal RNA and its association with systemic disease in middle-aged and elderly patients.
Article in Biomedical reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- The Effect of 6-Week Advanced Oral Care on Oral Microbiome and Mycobiome Composition in People With Dementia Living in Residential Aged Care.Clinical and experimental dental research · 2025Article
- Perspectives on tongue coating: etiology, clinical management, and associated diseases - a narrative review.The Saudi dental journal · 2025Review
- Key Bacterial Taxa Differences Associated with Polypharmacy in Elderly Patients.Microorganisms · 2025Article
- The association between the oral microbiome and hypertension: a systematic review.Journal of oral microbiology · 2025Article
- The Oral Microbiota, Microbial Metabolites, and Immuno-Inflammatory Mechanisms in Cardiovascular Disease.International journal of molecular sciences · 2024Review
- Prevalence of oralBiomedical reports · 2024Article
- Unexpected lower level of oral periodontal pathogens in patients with high numbers of systemic diseases.PeerJ · 2023Article
- Oral microbiome as a co-mediator of halitosis and periodontitis: a narrative review.Frontiers in oral health · 2023Review
- The role of the oral microbiome in smoking-related cardiovascular risk: a review of the literature exploring mechanisms and pathways.Journal of translational medicine · 2022Review
- Co-Infection of OralMedicina (Kaunas, Lithuania) · 2022Article
- The oral microbiome in alcohol use disorder: a longitudinal analysis during inpatient treatment.Journal of oral microbiology · 2022Article
- Association of oral Epstein-Barr virus with periodontal health in Japanese adults.Experimental and therapeutic medicine · 2021Article
- An evaluation of direct PCR assays for the detection and quantification ofEpidemiology and infection · 2020Article
- Detection of Red complex bacteria,Journal of family medicine and primary care · 2020Article
- High Rate of OralGeriatrics (Basel, Switzerland) · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association between oral health and systemic disease is recognized in the literature. The present study aimed to clarify the association between oral bacteria on the tongue dorsum and factors associated with oral health and systemic disease in middle-aged and elderly patients. The association between bacterial numbers, oral health status and systemic disease was preliminarily investigated in 70 patients (mean age, 69.5 years; range, 45-92 years) who visited the Department of Oral Health, Hiroshima University Hospital (Hiroshima, Japan). The bacterial 16S ribosomal RNA gene was employed to quantitate bacterial numbers using real-time polymerase chain reaction (PCR). PCR was also performed to detect the DNA of periodontal disease-related bacteria. Oral bacterial numbers were marginally negatively correlated with moisture levels on the tongue surface [Spearman's rank correlation coefficient (R)=-0.131, P=0.28). Subjects with bleeding on probing (BOP) or a ≥4 mm probing depth (PD) exhibited higher
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