ArticleLight, science & applications2018
Optoacoustic microscopy at multiple discrete frequencies.
Article in Light, science & applications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Image Quality Improvement Techniques and Assessment Adequacy in Clinical Optoacoustic Imaging: A Systematic Review.Biosensors · 2022Pooled it
- Frequency-domain photoacoustic microscopy with resonant transducer and interferometric modulation for high-reliability sOPhotoacoustics · 2026Article
- Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Sub-Diffraction Photoacoustic Microscopy Enabled by a Novel Phase-Shifted Excitation Strategy: A Numerical Study.Sensors (Basel, Switzerland) · 2026Article
- Advanced Microscopy Techniques.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- A comprehensive review of high-performance photoacoustic microscopy systems.Photoacoustics · 2025Review
- Towards affordable biomedical imaging: Recent advances in low-cost, high-resolution optoacoustic microscopy.Journal of microscopy · 2025Review
- Nanoporous Submicron Gold Particles Enable Nanoparticle-Based Localization Optoacoustic Tomography (nanoLOT).Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Ultrasound sensing with optical microcavities.Light, science & applications · 2024Review
- Overdriven laser diode optoacoustic microscopy.Scientific reports · 2023Article
- Observing temporal variation in hemolysis through photoacoustics with a low cost LASER diode based system.Scientific reports · 2023Article
- Frequency wavelength multiplexed optoacoustic tomography.Nature communications · 2022Article
- Two octaves spanning photoacoustic microscopy.Scientific reports · 2022Article
- Nanosecond SRS fiber amplifier for label-free near-infrared photoacoustic microscopy of lipids.Photoacoustics · 2022Article
- Detection of weak optical absorption by optical-resolution photoacoustic microscopy.Photoacoustics · 2022Article
- Label-free concurrent 5-modal microscopy (Co5M) resolves unknown spatio-temporal processes in wound healing.Communications biology · 2021Article
- A Cost-Efficient Multiwavelength LED-Based System for Quantitative Photoacoustic Measurements.Sensors (Basel, Switzerland) · 2021Article
- Optoacoustic imaging in endocrinology and metabolism.Nature reviews. Endocrinology · 2021Review
- In vitro optoacoustic flow cytometry with light scattering referencing.Scientific reports · 2021Article
- GPU-accelerated 3D volumetric X-ray-induced acoustic computed tomography.Biomedical optics express · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optoacoustic (photoacoustic) sensing employs illumination of transient energy and is typically implemented in the time domain using nanosecond photon pulses. However, the generation of high-energy short photon pulses requires complex laser technology that imposes a low pulse repetition frequency (PRF) and limits the number of wavelengths that are concurrently available for spectral imaging. To avoid the limitations of working in the time domain, we have developed frequency-domain optoacoustic microscopy (FDOM), in which light intensity is modulated at multiple discrete frequencies. We integrated FDOM into a hybrid system with multiphoton microscopy, and we examine the relationship between image formation and modulation frequency, showcase high-fidelity images with increasing numbers of modulation frequencies from phantoms and in vivo, and identify a redundancy in optoacoustic measurements performed at multiple frequencies. We demonstrate that due to high repetition rates, FDOM achieves signal-to-noise ratios similar to those obtained by time-domain methods, using commonly available laser diodes. Moreover, we experimentally confirm various advantages of the frequency-domain implementation at discrete modulation frequencies, including concurrent illumination at two wavelengths that are carried out at different modulation frequencies as well as flow measurements in microfluidic chips and in vivo based on the optoacoustic Doppler effect. Furthermore, we discuss how FDOM redefines possibilities for optoacoustic imaging by capitalizing on the advantages of working in the frequency domain.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.