Evidence map›Paper›PMID 30588086›Full record

ArticleBreast cancer (Dove Medical Press)2019

LXR/RXR pathway signaling associated with triple-negative breast cancer in African American women.

Odalys Torres-Luquis, Krystal Madden, N'sanh Mr N'dri, Richard Berg, Olufunmilayo F Olopade, Wilfred Ngwa, Dafalla Abuidris, Suresh Mittal, Beverly Lyn-Cook, Sulma I Mohammed

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer (Dove Medical Press), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Cholesterol, Oxysterols and LXRs in Breast Cancer Pathophysiology.International journal of molecular sciences · 2020
    Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Odalys Torres-LuquisDepartment of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA, mohammes@purdue.edu.
Krystal MaddenDepartment of Learning Sciences, University of Illinois at Chicago, Chicago, IL, USA.
N'sanh Mr N'driDepartment of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA, mohammes@purdue.edu.
Richard BergDepartment of Surgery, Indiana University Health, Lafayette, IN, USA.
Olufunmilayo F OlopadeCenter for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago, Chicago, IL, USA.
Wilfred NgwaDepartment of Radiation Oncology, Brigham and Women's Hospital, Boston, MA, USA.
Dafalla AbuidrisDepartment of Oncology, National Cancer Institute, University of Gezira, Gezira, Sudan.
Suresh MittalDepartment of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA, mohammes@purdue.edu.
Beverly Lyn-CookDivision of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, USA.
Sulma I MohammedDepartment of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA, mohammes@purdue.edu.
Purdue University West Lafayette · USBrigham and Women's Hospital · USIndiana University Health · USNational Center for Toxicological Research · USUniversity of Chicago · USUniversity of Gezira · SDUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTriple-negative breast cancer (TNBC) is more prevalent in African and African American (AA) women compared to European American (EA) women. African and AA women diagnosed with TNBC experience high frequencies of metastases and less favorable outcomes. Emerging evidence indicates that this disparity may in fact be the result of the uniquely aggressive biology of African and AA disease. PURPOSE: To understand the reasons for TNBC in AA aggressive biology, we designed the present study to examine the proteomic profiles of TNBC and luminal A (LA) breast cancer within and across patients' racial demographic groups in order to identify proteins or molecular pathways altered in TNBC that offer some explanation for its aggressiveness and potential targets for treatment. MATERIALS AND

methodsProteomic profiles of TNBC, LA tumors, and their adjacent normal tissues from AA and EA women were obtained using 2-dimensional gel electrophoresis and bioinformatics, and differentially expressed proteins were validated by Western blot and immunohistochemistry. Our data showed that a number of proteins have significantly altered in expression in LA tumors compared to TNBC, both within and across patients' racial demographic groups. The differentially overexpressed proteins in TNBC (compared to LA) of AA samples were distinct from those in TNBC (compared to LA) of EA women samples. Among the signaling pathways altered in AA TNBC compared to EA TNBC are innate immune signaling, calpain protease, and pyrimidine de novo synthesis pathways. Furthermore, liver LXR/RXR signaling pathway was altered between LA and TNBC in AA women and may be due to the deficiency of the CYP7B1 enzyme responsible for cholesterol degradation.

conclusionThese findings suggest that TNBC in AA women enriched in signaling pathways that are different from TNBC in EA women. Our study draws a link between LXR/RXR expression, cholesterol, obesity, and the TNBC in AA women.

Indexed as

African AmericanbreastEuropean Americanluminalluminal breast cancertriple-negative breast cancer

Identifiers

PMID30588086
PMCPMC6304259
OpenAlexW2904363145

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.