ArticleJournal of pain research2018
A model of neuropathic pain in brachial plexus avulsion injury and associated spinal glial cell activation.
Article in Journal of pain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Microglia-derived neuroinflammatory pathways in neuropathic pain.The Korean journal of pain · 2026Review
- Review
- Nociceptor-localized KCC2 suppresses brachial plexus avulsion-induced neuropathic pain and related central sensitization.Cell & bioscience · 2025Article
- Methylcobalamin in Combination with Early Intervention of Low-Intensity Pulsed Ultrasound Potentiates Nerve Regeneration and Functional Recovery in a Rat Brachial Plexus Injury Model.International journal of molecular sciences · 2023Article
- Acetylglutamine facilitates motor recovery and alleviates neuropathic pain after brachial plexus root avulsion in rats.Journal of translational medicine · 2023Article
- miR-506-3p Relieves Neuropathic Pain following Brachial Plexus Avulsion via Mitigating Microglial Activation through Targeting the CCL2-CCR2 Axis.Developmental neuroscience · 2023Article
- Quercetin Ameliorates Neuropathic Pain after Brachial Plexus AvulsionCurrent neuropharmacology · 2023Article
- Involvement of the BDNF-TrkB-KCC2 pathway in neuropathic pain after brachial plexus avulsion.Brain and behavior · 2022Article
- Early Intervention of Cold-Water Swimming on Functional Recovery and Spinal Pain Modulation Following Brachial Plexus Avulsion in Rats.International journal of molecular sciences · 2022Article
- Site of Nerve Division Affects Pain-Related Behavior and Spinal Cord Glial Proliferation after C7 Neurotomy in a Rat Stroke Model.Pain research & management · 2022Article
- The influence of shoulder arthrodesis on the function of the upper limb in adult patients after a brachial plexus injury: a systematic literature review with elements of meta-analysis.EFORT open reviews · 2021Review
- Transferrin receptor 1 plays an important role in muscle development and denervation-induced muscular atrophy.Neural regeneration research · 2021Article
- Comparison of Different In Vivo Animal Models of Brachial Plexus Avulsion and Its Application in Pain Study.Neural plasticity · 2020Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuropathic pain is a common and intractable sequel of brachial plexus injury. MATERIALS AND
methodsTo investigate the underlying mechanisms, we established a unique model of neuropathic pain in rats by creating brachial plexus avulsion injury.
resultsBehavioral test of mechanical stimulation suggested that all rats developed neuropathic pain, and the pain thresholds of bilateral hind limbs significantly decreased. GFAP expression in the cervical spinal cord appeared on day 1 post-injury and increased on day 4. Ionized calcium-binding adaptor molecule 1 expression appeared on day 1 post-injury and increased until day 28. Therefore, the brachial plexus avulsion injury model can imitate the development of neuropathic pain and maintain it.
conclusionThe activation of astrocyte and microglia in the spinal cord plays a key role in the mechanism and treatment of neuropathic pain.
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