Evidence map›Paper›PMID 30587976›Full record

ArticleInternational journal of nanomedicine2018

Eco-friendly synthesis, characterization, in vitro and in vivo anti-inflammatory activity of silver nanoparticle-mediated

Philippe Belle Ebanda Kedi, Francois Eya'ane Meva, Lebogang Kotsedi, Edwige Laure Nguemfo, Calvin Bogning Zangueu, Agnes Antoinette Ntoumba, Hamza Elsayed Ahmed Mohamed, Alain Bertrand Dongmo, Malik Maaza

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Design of a Gelatin/Carboxymethyl Cellulose Hydrogel Containing Myrtus Communis Extract with Anti-inflammatory Capabilities for Accelerated Wound Healing; in Vitro and in Vivo Study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
    Article
  5. Review
  6. Eco-friendly Cu-TiOAMB Express · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Green Synthesis of Silver Nanoparticles fromPharmaceutical nanotechnology · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Philippe Belle Ebanda KediDepartment of Animal Biology and Physiology, Faculty of Science, University of Douala, Douala, Cameroon, alainberd@yahoo.fr.
Francois Eya'ane MevaDepartment of Pharmaceutical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon, mevae@daad-alumni.de.
Lebogang KotsediNanosciences African Network (NANOAFNET), iThemba LABS-National Research Foundation, Somerset, South Africa.
Edwige Laure NguemfoDepartment of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon.
Calvin Bogning ZangueuDepartment of Animal Biology and Physiology, Faculty of Science, University of Douala, Douala, Cameroon, alainberd@yahoo.fr.
Agnes Antoinette NtoumbaDepartment of Animal Biology and Physiology, Faculty of Science, University of Douala, Douala, Cameroon, alainberd@yahoo.fr.
Hamza Elsayed Ahmed MohamedNanosciences African Network (NANOAFNET), iThemba LABS-National Research Foundation, Somerset, South Africa.
Alain Bertrand DongmoDepartment of Animal Biology and Physiology, Faculty of Science, University of Douala, Douala, Cameroon, alainberd@yahoo.fr.
Malik MaazaNanosciences African Network (NANOAFNET), iThemba LABS-National Research Foundation, Somerset, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere is emerging interest in medicinal plants in the biomedical field, due to their multitude of chemicals which show anti-inflammatory, antimicrobial, antiviral, or antitumoral potential. Research on medicinal plants has shown that nanotechnology could offer new solutions in the quality control, delivery aspects, or in sustaining herbal biological activities. This work reports on the preparation and characterization of silver nanoparticle-mediated

methodsUltraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, powder X-ray diffraction, energy dispersive X-ray spectroscopy, high-resolution scanning electron microscopy, high-resolution transmission electron microscopy, and selected area electron diffraction have been used to characterize the prepared silver nanoparticles. The synthetic stability was studied by varying concentrations and pH of reactants. Egg albumin denaturation and carrageenan-induced rat paw edema model were used to ascertain the anti-inflammation.

resultsUltraviolet-visible spectroscopy gave plasmon resonance ranging between 420 and 480 nm while Fourier transform infrared spectroscopy proved nano interface functionalized with organics. The powder X-ray diffraction pattern is in agreement with silver and silver chloride nanoparticles of crystallite size 33.7 nm and 44.2 nm for silver and silver chloride, respectively. Energy dispersive X-ray spectroscopy enables elemental characterization of the particles consisting of silver and silver chloride among main elements. Spherical silver grain of 58.81 nm average size has been depicted with high-resolution scanning electron microscopy and high-resolution transmission electron microscopy. Inhibitions of 99% and 60% were obtained in vitro and in vivo, respectively.

conclusionThe albumin denaturation and carrageenan-induced rat hind paw edema model to assess the anti-inflammatory potential of generated nanoparticles suggests that the silver nanoparticles may act as reducing/inhibiting agents on the release of acute inflammatory mediators. Hence, this work clearly demonstrated that silver nanoparticles mediated-

Indexed as

AlbuminsAnimalsAnti-Infective AgentsAnti-Inflammatory AgentsCarrageenanEdemaGreen Chemistry TechnologyHydrogen-Ion ConcentrationMetal NanoparticlesPlant ExtractsProtein DenaturationRats, WistarSelaginellaceaeSilverSpectrometry, X-Ray EmissionSpectrophotometry, UltravioletAlbuminsAnti-Infective AgentsAnti-Inflammatory AgentsCarrageenanPlant ExtractsSilveranti-inflammatoryeco-friendly synthesisSelaginella myosurussilver nanoparticles

Identifiers

PMID30587976
PMCPMC6296690

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.