Evidence map›Paper›PMID 30587972›Full record

ReviewInternational journal of nanomedicine2018

Nanoparticle-conjugated nutraceuticals exert prospectively palliative of amyloid aggregation.

Kiran Reddy Kanubaddi, Shin-Han Yang, Li-Wei Wu, Chia-Hung Lee, Ching-Feng Weng

Open access · goldAbstract readReview
In one paragraph

Review in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. International journal of molecular sciences · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kiran Reddy KanubaddiDepartment of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan, cfweng@gms.ndhu.edu.tw.
Shin-Han YangDepartment of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan, cfweng@gms.ndhu.edu.tw.
Li-Wei WuDepartment of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan, cfweng@gms.ndhu.edu.tw.
Chia-Hung LeeDepartment of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan, cfweng@gms.ndhu.edu.tw.
Ching-Feng WengDepartment of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan, cfweng@gms.ndhu.edu.tw.
National Dong Hwa University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD), an age-related neurodegenerative disease, the most common causes of dementia is a multifactorial pathology categorized by a complex etiology. Numerous nutraceuticals have been clinically evaluated, but some of the trials failed. However, natural compounds have some limitations due to their poor bioavailability, ineffective capability to cross the blood-brain barrier, or less therapeutic effects on AD. To overcome these disadvantages, nanoparticle-conjugated natural products could promote the bioavailability and enhance the therapeutic efficacy of AD when compared with a naked drug. This application generates and implements new prospect for drug discovery in neurodegenerative diseases. In this article, we confer AD pathology, review natural products in clinical trials, and ascertain the importance of nanomedicine coupled with natural compounds for AD.

Indexed as

Dietary SupplementsAlzheimer DiseaseAmyloidBiological ProductsHumansNanoparticlesAmyloidBiological ProductsAlzheimer’s diseaseamyloid betabioavailabilitynatural productsnutraceuticals

Identifiers

PMID30587972
PMCPMC6294069
OpenAlexW2905195326

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.