ArticlePatient preference and adherence2019
Adherence to medical regimen after pediatric liver transplantation: a systematic review and meta-analysis.
Article in Patient preference and adherence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Medication self-management during the developmental transition of responsibility among Chinese adolescent liver transplant recipients: a qualitative descriptive study.European journal of pediatrics · 2026Article
- Bridging the Gap: A Review of Pediatric to Adult Transition of Care in Liver Transplantation.Pediatric transplantation · 2025Review
- Risk Factors for Non-Adherence to Medication for Liver Transplant Patients: An Umbrella Review.Journal of clinical medicine · 2024Review
- Biliary Atresia in Adolescence and Adult Life: Medical, Surgical and Psychological Aspects.Journal of clinical medicine · 2023Review
- Long-Term Cognitive Outcomes and Associated Quality of Life of Young Adults Who Experienced Liver Transplantation in Early Childhood.Frontiers in transplantation · 2022Article
- Study of Adherence to Medication in Pediatric Liver Diseases ("SAMPLD" Study) in Indian Children.Journal of clinical and experimental hepatologyArticle
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAdherence to the medical regimen after pediatric liver transplantation is crucial for good clinical outcomes. However, the existing literature provides inconsistent evidence regarding the prevalence of and risk factors for nonadherence to the medical regimen after pediatric liver transplantation. This study aimed to investigate such nonadherence after pediatric liver transplantation and risk factors associated with this nonadherence using findings of reported studies.
methodsThe electronic databases of Excerpta Medica, Ovid Technologies, PubMed and WanFang Data were searched using the keywords "adherence", "liver transplant" and "paediatric". Additionally, relevant references cited in related studies were used to obtain original articles. Using 22 original articles, data regarding nonadherence to the medical regimen after pediatric liver transplantation were quantitatively combined, and risk factors associated with nonadherence were qualitatively identified. Average rates of nonadherence in four areas of medical regimens were calculated. The heterogeneity of the included original articles was also analyzed. When
resultsThe clinical attendance nonadherence rate was 45% (95% confidence interval [CI]: 39-51), global nonadherence rate was 17% (95% CI: 13-21) and immunosuppression non-adherence rates were 39% (95% CI: 26-52) and 34% (95% CI: 30-39) for cyclosporine and tacrolimus, respectively. Risk factors included older age of the pediatric patient, low family cohesion, poor social functioning, poor mental health and single-parent family.
conclusionsThe nonadherence rate in pediatric liver transplantation is high. Therefore, intervention on the basis of risk factors, such as mental health and family function, may be necessary. Moreover, a standard technique for assessing nonadherence to the medical regimen after pediatric liver transplantation, comprising as many dimensions as possible, is required in order to be more objective and comprehensive when assessing nonadherence.
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