ArticleThe Journal of veterinary medical science2019
Pre-pubertal exposure to high temperature impairs ovarian and adrenal gland function in female rats.
Article in The Journal of veterinary medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- The impact of season, temperature, and direct normal irradiance on IVF pregnancy outcomes: a retrospective cohort study.International journal of biometeorology · 2025Article
- Allostasis in Neuroendocrine Systems Controlling Reproduction.Endocrinology · 2023Review
- Climate change and pregnancy complications: From hormones to the immune response.Frontiers in endocrinology · 2023Review
- Characteristics of menstrual cycle disorder and saliva metabolomics of young women in a high-temperature environment.Frontiers in physiology · 2022Article
- Understanding how environmental factors influence reproductive aspects of wild myomorphic and hystricomorphic rodents.Animal reproduction · 2021Review
- Integrative Analysis of Vaginal Microorganisms and Serum Metabolomics in Rats With Estrous Cycle Disorder Induced by Long-Term Heat Exposure Based on 16S rDNA Gene Sequencing and LC/MS-Based Metabolomics.Frontiers in cellular and infection microbiology · 2021Article
- Pathophysiological Changes in Female Rats with Estrous Cycle Disorder Induced by Long-Term Heat Stress.BioMed research international · 2020Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influence of different levels of heat exposure on the functions of ovarian and adrenal gland were investigated in pre-puberty female rats. Three-week old female rats were treated with control (26°C) or three higher temperatures (38, 40 and 42°C) for 2hr/day. After 9 days of treatment, blood samples were collected for measurement of luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol-17β, corticosterone, cholesterol and triglyceride. Adrenal glands, ovaries and liver were collected for analyzing gene expressions. Body and liver weight were significantly low in the 42°C heating group. Circulating LH and triglyceride in the 42°C heating group were significantly lower, and estradiol-17β, corticosterone and cholesterol were significantly higher than those of the control group. The gene expression of 3β-HSD and P450c21 in the adrenal gland; 3β-HSD, receptors of LH, FSH and estrogen in the ovary were significantly low in heated rats. The liver gene expressions of caspase 3 and NK-κB were significantly high in 42°C heated rats, suggesting that the ability of liver metabolic function reduced in the 42°C heated rats. These results demonstrated that the high temperature is responsible for suppression of ovarian function by decreasing the expression of steroidogenic enzymes, estrogen and gonadotropin receptors in the ovary. Increase in circulating estradiol-17β in the heated rats may be due to accumulate this hormone in circulation by potential changes in liver metabolism during the heat stress.
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