Evidence map›Paper›PMID 30587573›Full record

ArticleThe Journal of biological chemistry2019

ATP binding without hydrolysis switches sulfonylurea receptor 1 (SUR1) to outward-facing conformations that activate K

Jelena Sikimic, Timothy S McMillen, Cita Bleile, Frank Dastvan, Ulrich Quast, Peter Krippeit-Drews, Gisela Drews, Joseph Bryan

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Clinical and Genetic Characteristics ofJournal of diabetes research · 2021
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Dynamic duo: Kir6 and SUR in KChannels (Austin, Tex.) · 2024
    Review
  7. Article
  8. Review
  9. Development of IFrontiers in pharmacology · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jelena SikimicFrom the Institute of Pharmacy, Department of Pharmacology, University of Tübingen, D-72076 Tübingen, Germany and.
Timothy S McMillenPacific Northwest Diabetes Research Institute, Seattle, Washington 98122, and.
Cita BleileFrom the Institute of Pharmacy, Department of Pharmacology, University of Tübingen, D-72076 Tübingen, Germany and.
Frank DastvanPacific Northwest Diabetes Research Institute, Seattle, Washington 98122, and.
Ulrich QuastDepartment of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, D-72074 Tübingen, Germany.
Peter Krippeit-DrewsFrom the Institute of Pharmacy, Department of Pharmacology, University of Tübingen, D-72076 Tübingen, Germany and.
Gisela DrewsFrom the Institute of Pharmacy, Department of Pharmacology, University of Tübingen, D-72076 Tübingen, Germany and.ORCID 0000-0002-0756-4816
Joseph BryanPacific Northwest Diabetes Research Institute, Seattle, Washington 98122, and jbryan1941@outlook.com.
University of Tübingen · DEPacific Northwest Diabetes Research Institute · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Challenging the Dominant Model for ATP Regulation of KATP ChannelsR01DK098647 · NIDDK · PACIFIC NORTHWEST RESEARCH INSTITUTE · PI BRYAN, JOSEPH · 2014 to 2017
$1.4M
NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK098647
6 · The paper itself

Abstract

Neuroendocrine-type ATP-sensitive K

Indexed as

Adenosine DiphosphateAdenosine TriphosphateAllosteric RegulationAnimalsBinding SitesCricetinaeGuanosine TriphosphateHEK293 CellsHumansHydrolysisIon Channel GatingKcnj11 ChannelModels, MolecularMutationPotassium Channels, Inwardly RectifyingProtein BindingABCC8 protein, humanAdenosine DiphosphateAdenosine TriphosphateGuanosine TriphosphateKcnj11 ChannelPotassium Channels, Inwardly RectifyingSulfonylurea ReceptorsABC transporterallosteric regulationATP-binding cassette transporter subfamily C member 8 (ABCC8)ATP-sensitive potassium channelcongenital hyperinsulinismdiabetesglibenclamidehyperinsulinismion channelKATP channelKCNJ11 (Kir6.2)metabolic sensorneonatal diabetesSUR1

Identifiers

PMID30587573
PMCPMC6416425
OpenAlexW2906528689

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.