ArticleNeurology2019
Aspirin reduces long-term stroke risk in women with prior hypertensive disorders of pregnancy.
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Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- Implementation of First-Trimester Screening and Prevention of Preeclampsia: A Stepped Wedge Cluster-Randomized Trial in Asia.Circulation · 2024Trial
- Closing the Gap Between Recommendation and Uptake: Provider Communication About Low-Dose Aspirin for Preeclampsia Prevention.Journal of pediatrics, perinatology and child health · 2026Article
- Longitudinal fetal growth parameters in women at high risk for pre-eclampsia.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Article
- Aspirin does not modify cardiovascular event risk in endometriosis in the California Teachers Study.European heart journal open · 2025Article
- Advances in Our Understanding of Cardiovascular Diseases After Preeclampsia.Circulation research · 2025Review
- Long-Term Exposure to Arsenic in Community Water Supplies and Risk of Cardiovascular Disease among Women in the California Teachers Study.Environmental health perspectives · 2024Article
- Stroke in Pregnancy and Preeclampsia: Effect of Low-Dose Aspirin Treatment on Collateral Flow Velocity and Cerebral Blood Flow Autoregulation During Ischemia in Rats.Journal of the American Heart Association · 2024Article
- Stroke vs. Preeclampsia: Dangerous Liaisons of Hypertension and Pregnancy.Medicina (Kaunas, Lithuania) · 2023Review
- Article
- Cardiovascular Disease-Related Emergency Department Visits and Hospitalization among Women with Hypertensive Disorders of Pregnancy.American journal of preventive medicine · 2023Article
- Article
- Pre-eclampsia and Cardiovascular Disease: From Pregnancy to Postpartum.European cardiology · 2023Review
- Women with Adverse Pregnancy Outcomes Have Higher Odds of Midlife Stroke: The Population Assessment of Tobacco and Health Study.Journal of women's health (2002) · 2022Article
- The Impact of Sex and Gender on Stroke.Circulation research · 2022Review
- Impact of Hypertensive Disorders of Pregnancy on the Risk of Stroke Stratified by Subtypes and Follow-Up Time.Stroke · 2022Article
- Review
- Neurology of Preeclampsia and Related Disorders: an Update in Neuro-obstetrics.Current pain and headache reports · 2021Review
- Hippocampal network dysfunction as a mechanism of early-onset dementia after preeclampsia and eclampsia.Progress in neurobiology · 2021Article
- Stroke in Pregnancy: A Multidisciplinary Approach.Obstetrics and gynecology clinics of North America · 2021Review
- Cardiovascular and cerebrovascular health after pre-eclampsia: the Motherhealth prospective cohort study protocol.BMJ open · 2021Article
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Authors and funding
12 authors at 1 institution in 2 countries.
Eliza C MillerFrom the Departments of Neurology (E.C.M., A.K.B., M.S.V.E., J.Z.W.), Medicine (N.A.B.), and Obstetrics and Gynecology (R.W.), Columbia University; Department of Epidemiology (A.K.B., M.S.V.E.), Columbia University Mailman School of Public Health, New York, NY; Department of Population Sciences (N.T.C., S.S.W., J.V.L., C.Z.), Beckman Research Institute and City of Hope National Medical Center, Duarte, CA; Department of Neurology (K.L.), University of Minnesota Medical Center, Minneapolis; and Department of Neurology (D.W.), University of Cincinnati Medical Center, OH. ecm2137@cumc.columbia.edu.ORCID 0000-0002-7108-8906
Amelia K BoehmeFrom the Departments of Neurology (E.C.M., A.K.B., M.S.V.E., J.Z.W.), Medicine (N.A.B.), and Obstetrics and Gynecology (R.W.), Columbia University; Department of Epidemiology (A.K.B., M.S.V.E.), Columbia University Mailman School of Public Health, New York, NY; Department of Population Sciences (N.T.C., S.S.W., J.V.L., C.Z.), Beckman Research Institute and City of Hope National Medical Center, Duarte, CA; Department of Neurology (K.L.), University of Minnesota Medical Center, Minneapolis; and Department of Neurology (D.W.), University of Cincinnati Medical Center, OH.ORCID 0000-0002-7109-6025
Nadia T ChungFrom the Departments of Neurology (E.C.M., A.K.B., M.S.V.E., J.Z.W.), Medicine (N.A.B.), and Obstetrics and Gynecology (R.W.), Columbia University; Department of Epidemiology (A.K.B., M.S.V.E.), Columbia University Mailman School of Public Health, New York, NY; Department of Population Sciences (N.T.C., S.S.W., J.V.L., C.Z.), Beckman Research Institute and City of Hope National Medical Center, Duarte, CA; Department of Neurology (K.L.), University of Minnesota Medical Center, Minneapolis; and Department of Neurology (D.W.), University of Cincinnati Medical Center, OH.
Sophia S WangFrom the Departments of Neurology (E.C.M., A.K.B., M.S.V.E., J.Z.W.), Medicine (N.A.B.), and Obstetrics and Gynecology (R.W.), Columbia University; Department of Epidemiology (A.K.B., M.S.V.E.), Columbia University Mailman School of Public Health, New York, NY; Department of Population Sciences (N.T.C., S.S.W., J.V.L., C.Z.), Beckman Research Institute and City of Hope National Medical Center, Duarte, CA; Department of Neurology (K.L.), University of Minnesota Medical Center, Minneapolis; and Department of Neurology (D.W.), University of Cincinnati Medical Center, OH.
James V LaceyFrom the Departments of Neurology (E.C.M., A.K.B., M.S.V.E., J.Z.W.), Medicine (N.A.B.), and Obstetrics and Gynecology (R.W.), Columbia University; Department of Epidemiology (A.K.B., M.S.V.E.), Columbia University Mailman School of Public Health, New York, NY; Department of Population Sciences (N.T.C., S.S.W., J.V.L., C.Z.), Beckman Research Institute and City of Hope National Medical Center, Duarte, CA; Department of Neurology (K.L.), University of Minnesota Medical Center, Minneapolis; and Department of Neurology (D.W.), University of Cincinnati Medical Center, OH.
Kamakshi LakshminarayanFrom the Departments of Neurology (E.C.M., A.K.B., M.S.V.E., J.Z.W.), Medicine (N.A.B.), and Obstetrics and Gynecology (R.W.), Columbia University; Department of Epidemiology (A.K.B., M.S.V.E.), Columbia University Mailman School of Public Health, New York, NY; Department of Population Sciences (N.T.C., S.S.W., J.V.L., C.Z.), Beckman Research Institute and City of Hope National Medical Center, Duarte, CA; Department of Neurology (K.L.), University of Minnesota Medical Center, Minneapolis; and Department of Neurology (D.W.), University of Cincinnati Medical Center, OH.ORCID 0000-0002-8564-8986
Charlie ZhongFrom the Departments of Neurology (E.C.M., A.K.B., M.S.V.E., J.Z.W.), Medicine (N.A.B.), and Obstetrics and Gynecology (R.W.), Columbia University; Department of Epidemiology (A.K.B., M.S.V.E.), Columbia University Mailman School of Public Health, New York, NY; Department of Population Sciences (N.T.C., S.S.W., J.V.L., C.Z.), Beckman Research Institute and City of Hope National Medical Center, Duarte, CA; Department of Neurology (K.L.), University of Minnesota Medical Center, Minneapolis; and Department of Neurology (D.W.), University of Cincinnati Medical Center, OH.
Daniel WooFrom the Departments of Neurology (E.C.M., A.K.B., M.S.V.E., J.Z.W.), Medicine (N.A.B.), and Obstetrics and Gynecology (R.W.), Columbia University; Department of Epidemiology (A.K.B., M.S.V.E.), Columbia University Mailman School of Public Health, New York, NY; Department of Population Sciences (N.T.C., S.S.W., J.V.L., C.Z.), Beckman Research Institute and City of Hope National Medical Center, Duarte, CA; Department of Neurology (K.L.), University of Minnesota Medical Center, Minneapolis; and Department of Neurology (D.W.), University of Cincinnati Medical Center, OH.
Natalie A BelloFrom the Departments of Neurology (E.C.M., A.K.B., M.S.V.E., J.Z.W.), Medicine (N.A.B.), and Obstetrics and Gynecology (R.W.), Columbia University; Department of Epidemiology (A.K.B., M.S.V.E.), Columbia University Mailman School of Public Health, New York, NY; Department of Population Sciences (N.T.C., S.S.W., J.V.L., C.Z.), Beckman Research Institute and City of Hope National Medical Center, Duarte, CA; Department of Neurology (K.L.), University of Minnesota Medical Center, Minneapolis; and Department of Neurology (D.W.), University of Cincinnati Medical Center, OH.ORCID 0000-0003-3257-3623
Ronald WapnerFrom the Departments of Neurology (E.C.M., A.K.B., M.S.V.E., J.Z.W.), Medicine (N.A.B.), and Obstetrics and Gynecology (R.W.), Columbia University; Department of Epidemiology (A.K.B., M.S.V.E.), Columbia University Mailman School of Public Health, New York, NY; Department of Population Sciences (N.T.C., S.S.W., J.V.L., C.Z.), Beckman Research Institute and City of Hope National Medical Center, Duarte, CA; Department of Neurology (K.L.), University of Minnesota Medical Center, Minneapolis; and Department of Neurology (D.W.), University of Cincinnati Medical Center, OH.ORCID 0000-0003-0727-1244
Mitchell S V ElkindFrom the Departments of Neurology (E.C.M., A.K.B., M.S.V.E., J.Z.W.), Medicine (N.A.B.), and Obstetrics and Gynecology (R.W.), Columbia University; Department of Epidemiology (A.K.B., M.S.V.E.), Columbia University Mailman School of Public Health, New York, NY; Department of Population Sciences (N.T.C., S.S.W., J.V.L., C.Z.), Beckman Research Institute and City of Hope National Medical Center, Duarte, CA; Department of Neurology (K.L.), University of Minnesota Medical Center, Minneapolis; and Department of Neurology (D.W.), University of Cincinnati Medical Center, OH.ORCID 0000-0003-2562-1156
Joshua Z WilleyFrom the Departments of Neurology (E.C.M., A.K.B., M.S.V.E., J.Z.W.), Medicine (N.A.B.), and Obstetrics and Gynecology (R.W.), Columbia University; Department of Epidemiology (A.K.B., M.S.V.E.), Columbia University Mailman School of Public Health, New York, NY; Department of Population Sciences (N.T.C., S.S.W., J.V.L., C.Z.), Beckman Research Institute and City of Hope National Medical Center, Duarte, CA; Department of Neurology (K.L.), University of Minnesota Medical Center, Minneapolis; and Department of Neurology (D.W.), University of Cincinnati Medical Center, OH.ORCID 0000-0001-5180-2044
University of Minnesota Medical Center · US
Funding
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0MHealth Disparities in Sepsis as a Risk Factor for StrokeR03NS101417 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BOEHME, AMELIA K · 2017 to 2018
$160kNCATS NIH HHS UL1 TR001873NINDS NIH HHS R03 NS101417
Abstract
objectiveTo determine whether hypertensive disorders of pregnancy (HDP) increased long-term stroke risk in women in the California Teachers Study (CTS), a prospective cohort study, and whether aspirin or statin use modified this risk.
methodsCTS participants ≤60 years of age at the time of enrollment in 1995 were followed up prospectively for validated stroke outcomes obtained via linkage with California hospital records through December 31, 2015. We calculated unadjusted and adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the primary outcomes of all stroke and stroke before 60 years of age among those with and without a history of HDP. We tested for interactions (
resultsOf 83,749 women included in the analysis, 4,070 (4.9%) had HDP. Women with prior HDP had increased risk of all stroke (adjusted HR 1.3, 95% CI 1.2-1.4) but no increased risk of stroke before age 60 (adjusted HR 1.2, 95% CI 0.9-1.7). There was an interaction (
conclusionsAfter controlling for comorbid conditions, women with prior HDP had increased long-term stroke risk, which was reduced by aspirin use. Randomized trials may be needed to assess whether long-term aspirin use could benefit selected women with a history of HDP.
Indexed as
AdultAge FactorsAspirinFemaleFibrinolytic AgentsFollow-Up StudiesHospitalistsHumansHypertension, Pregnancy-InducedMiddle AgedPregnancyStrokeSurveys and QuestionnairesTreatment OutcomeUnited StatesAspirinFibrinolytic Agents
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