Evidence map›Paper›PMID 30587501›Full record

ArticleCancer genomics & proteomics

MiR-1 Suppresses Proliferation of Osteosarcoma Cells by Up-regulating p21

Ryota Fujii, Eiji Osaka, Kentaro Sato, Yasuaki Tokuhashi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ryota FujiiDepartment of Orthopaedic Surgery, Nihon University School of Medicine, Tokyo, Japan.
Eiji OsakaDepartment of Orthopaedic Surgery, Nihon University School of Medicine, Tokyo, Japan osaka.eiji@nihon-u.ac.jp.
Kentaro SatoDepartment of Orthopaedic Surgery, Nihon University School of Medicine, Tokyo, Japan.
Yasuaki TokuhashiDepartment of Orthopaedic Surgery, Nihon University School of Medicine, Tokyo, Japan.
Nihon University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimmiRNA-1(miR-1) is down-regulated in various cancer cells including osteosarcoma cells. This study was conducted to analyze the function of miR-1 in osteosarcoma cells. MATERIALS AND

methodsmiR-1 expression in osteosarcoma cells was evaluated by qRT-PCR. Cell proliferation was evaluated after transfecting miR-1 by WST8 assay and FACS analysis, both in vitro and in vivo.

resultsOverexpression of miR-1 suppressed cell proliferation and induced cell-cycle arrest in the G

conclusionOverexpression of miR-1 suppressed cell proliferation and induced arrest in the G

Indexed as

Gene Expression Regulation, NeoplasticRNA InterferenceApoptosisBone NeoplasmsCell CycleCell Line, TumorCyclin-Dependent Kinase Inhibitor p21HumansMicroRNAsOsteosarcomaPAX3 Transcription FactorSignal TransductionTumor Suppressor Protein p53CDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21MicroRNAsMIRN1 microRNA, humanPAX3 protein, humanPAX3 Transcription FactorTumor Suppressor Protein p53miR-1Osteosarcomap21p53-independent pathwayPAX3

Identifiers

PMID30587501
PMCPMC6348397
OpenAlexW2906058936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.