ArticleClinical epigenetics2018
DNA methylation age is not affected in psoriatic skin tissue.
Article in Clinical epigenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Skin aging: mechanisms, evaluation, and rejuvenation.The EMBO journal · 2026Review
- Unraveling the complexity of skin's biological aging utilizing epigenetic clocks.Clinical epigenetics · 2026Article
- A Strong Dysregulated Myeloid Component in the Epigenetic Landscape of Systemic Sclerosis: An Integrated DNA Methylome and Transcriptome Analysis.Arthritis & rheumatology (Hoboken, N.J.) · 2025Article
- Recent progress on DNA methylation in psoriasis.Frontiers in genetics · 2025Review
- Metagenomics reveals unique gut mycobiome biomarkers in psoriasis.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- A case-control study: epigenetic age acceleration in psoriasis.Archives of dermatological research · 2024Article
- A miRNA-based epigenetic molecular clock for biological skin-age prediction.Archives of dermatological research · 2024Article
- Psoriasis, Is It a Microdamage of Our "Sixth Sense"? A Neurocentric View.International journal of molecular sciences · 2022Article
- Exploration of Biomarkers of Psoriasis through Combined Multiomics Analysis.Mediators of inflammation · 2022Article
- Anti-tumor necrosis factor drug responses and skin-blood DNA methylation age: Relationships in moderate-to-severe psoriasis.Experimental dermatology · 2021Article
- Terminal keratinocyte differentiation in vitro is associated with a stable DNA methylome.Experimental dermatology · 2021Article
- Aging in psoriasis vulgaris: female patients are epigenetically older than healthy controls.Immunity & ageing : I & A · 2021Article
- Identification of Potential Biomarkers for Psoriasis by DNA Methylation and Gene Expression Datasets.Frontiers in genetics · 2021Article
- Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging.Clinical epigenetics · 2020Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPsoriasis (Ps) is a common chronic inflammatory skin disease. The keratinocytes of psoriatic skin defy normal apoptosis and exhibit active cell proliferation. Aberrant DNA methylation (DNAm) has been suggested relevant through regulating the expression of Ps susceptibility genes. However, it is unclear whether the biological age inferred from DNA methylome is affected.
resultsTo address the above issue, we applied a recently developed methylation clock model to our Chinese Han population dataset, which includes DNAm data of 114 involved psoriatic skin tissues (PP) and 41 uninvolved psoriatic skin tissues (PN) from Ps patients, and 62 normal skin tissues (NN) from health controls. We first confirmed the applicability of the clock in PN and NN. We then showed that PP samples have largely unchanged DNAm age, and that no association was observed between available clinical features and DNAm age acceleration. Examination of genome-wide CpGs yielded age-associated CpGs with concordant age-association coefficients among the three groups, which was also supported by an external dataset. We also interestingly observed two clock CpGs differentially methylated between PP and PN.
conclusionsOverall, our results suggest no significant alteration in DNAm age in PN and PP. Therefore, the increase in keratinocyte proliferation and alteration in DNAm caused by Ps may not affect the biological age of psoriatic skin tissue.
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