ArticleLipids in health and disease2018
The high maternal TG level at early trimester was associated with the increased risk of LGA newborn in non-obesity pregnant women.
Article in Lipids in health and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Maternal lipid levels in pregnant women without complications in developing risk of large for gestational age newborns: a study of meta-analysis.F1000Research · 2020Pooled it
- Cardiometabolic Markers Associated With Altered Fetal Growth in Mediterranean Cohort.Maternal & child nutrition · 2025Article
- Article
- Association of Triglyceride-Glucose Index with Risk of Large for Gestational Age: A Prospective Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Association of Triglyceride-Glucose Index with Risk of Large for Gestational Age: A Prospective Cohort Study [Letter].Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Ferroptosis-related gene expression in the pathogenesis of preeclampsia.Frontiers in genetics · 2022Article
- Changes in serum TG levels during pregnancy and their association with postpartum hypertriglyceridemia: a population-based prospective cohort study.Lipids in health and disease · 2021Article
- Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex: Secondary analysis of the DALI study.Pediatric obesity · 2020Article
- Life Course Trajectories of Maternal Cardiovascular Risk Factors according to Offspring Birthweight: The HUNT Study.Scientific reports · 2020Article
- Maternal Vascular Health in Pregnancy and Postpartum After Assisted Reproduction.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Being Born Large for Gestational Age is Associated with Increased Global Placental DNA Methylation.Scientific reports · 2020Article
- Lipid Profile Pattern among Women Screened for Hyperglycaemia in Pregnancy at the University of Jos Teaching Hospital, Nigeria.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
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8 authors at 1 institution in 1 country.
Funding
Abstract
introductionRecent research had shown blood glucose was not the only cause of large for gestational age infant (LGA), the contributions of other fuels such as lipids also play an important role in fetal development. However the association between maternal triglyceride at early trimester and the risk of LGA has not yet been clearly elucidated. This research evaluated the association of maternal early trimester TG level with the risk of LGA infant in Chinese mothers.
methods2839 pregnant women were recruited at the first visit of their perinatal health care and followed up prospectively till after delivery. The demographic, maternal characteristics were extracted from a questionnaire. Infant characteristics were collected at delivery. Maternal fasting serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (HDL-C)levels, were measured in 6~8th, 16th, 24th, and 36th gestational weeks. Fasting serum glucose levels were measured at 6~8th, 24th, and 36th gestational weeks. Logistic regression model was used to calculate the odds ratio (OR) and 95% confidence intervals.
resultsA consistently lower TG level was observed in mothers with non-LGA infant than mothers with LGA infant and TG level of mothers of LGA infants increased faster than that of control group. The incidence of LGA infants between two groups (TG<1.7 mmol/L and TG ≥ 1.7 mmol/L) was 14.46 and 26.63%, respectively. Mothers with the highest TG level (TG > 1.19 mmol/L) gave birth to infants with higher birth weight (BW) than the other two groups (TG < 0.70 mmol/L and TG:0.70~0.89 mmol/L). When stratified by pre-pregnancy body mass index (pre-BMI), a significantly positive association was founded between the maternal TG level at early trimester and the risk of LGA in non-overweight/obesity women (OR = 1.740, p = 0.034).
conclusionsThe findings suggested that high maternal TG level at very early trimester was associated with the increased risk of LGA in non-overweight/obesity pregnant women. Moreover, high maternal TG level at first trimester may be an early predictor of LGA.
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