ArticleBMC complementary and alternative medicine2018
Chebulinic acid derived from triphala is a promising antitumour agent in human colorectal carcinoma cell lines.
Article in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 43 citations in OpenAlex.
- Rambutan (Molecules (Basel, Switzerland) · 2026Article
- Unlocking the Therapeutic Potential of Ellagitannins: A Comprehensive Review of Key Representatives.Molecules (Basel, Switzerland) · 2025Review
- Triphala's characteristics and potential therapeutic uses in modern health.International journal of physiology, pathophysiology and pharmacology · 2025Review
- Herbal Interactions with Cardiac Medications: A Comprehensive Review of Potential Interactions between Herbal Drugs and Commonly Prescribed Cardiac Medications.Current drug safety · 2025Review
- Dual intervention of Boeravinone B and Chebulinic Acid mitigates BHT-Induced toxicity in HepG2 cells: modulating apoptosis and autophagy.Scientific reports · 2024Article
- Chebulinic acid isolated from aqueous extracts ofFrontiers in microbiology · 2024Article
- Non-toxic nature of chebulinic acid on biochemical, hematological and histopathological analysis in normal Sprague Dawley rats.Toxicological research · 2022Article
- Hepatoprotective Effects of Different Extracts FromFrontiers in pharmacology · 2021Article
- Identification and Characterization of Antimicrobial Peptides From Butterflies: An Integrated Bioinformatics and Experimental Study.Frontiers in microbiology · 2021Article
- Drug Design Strategies for the Treatment of Viral Disease. Plant Phenolic Compounds and Their Derivatives.Frontiers in pharmacology · 2021Review
- Protective Effect of Triphala against Oxidative Stress-Induced Neurotoxicity.BioMed research international · 2021Article
- Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala.Antioxidants (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTriphala is an Ayurvedic rasayana formulation reputed for its antitumour activities, and chebulinic acid and chebulagic acid, along with other phenolic acids, have been proposed to be responsible for its effects.
methodsIn this study, the anti-proliferative activities of these agents were evaluated in colorectal carcinoma cell lines with three phenotypes exposed to several batches of triphala samples with different quantities of chebulinic acid and chebulagic acid. The pro-apoptotic and anti-migratory activities and the probable antitumour mechanisms of the more potent anti-proliferative phytochemical were also investigated.
resultsThe results demonstrated that chebulinic acid, which exerts potent anti-proliferative, pro-apoptotic and anti-migratory effects, is a key molecule for maintaining the antitumour efficacy of triphala. The antitumour mechanism of chebulinic acid is probably related to the PI3K/AKT and MAPK/ERK pathways.
conclusionsChebulinic acid is not only a critical component of the anticancer activities of triphala but also a promising natural multi-target antitumour agent with therapeutic potential.
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