Evidence map›Paper›PMID 30587145›Full record

ArticleBMC infectious diseases2018

Human papillomavirus infection & anal cytological abnormalities in HIV-positive men in eastern India.

Abhilasha Gautam, Jaya Chakravarty, Vijay Kumar Singh, Amrita Ghosh, Shashi Bhushan Chauhan, Madhukar Rai, Shyam Sundar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Abhilasha GautamDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Jaya ChakravartyDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India. tapadar@gmail.com.ORCID http://orcid.org/0000-0001-9834-8053
Vijay Kumar SinghDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Amrita GhoshDepartment of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Shashi Bhushan ChauhanDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Madhukar RaiDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Shyam SundarDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Institute of Medical Sciences · IN

Funding

Centre of Excellence (COE), National AIDS Control Organization NACO (M-18017/72/2007/NACO (GF Rd 6), India.
6 · The paper itself

Abstract

backgroundOncogenic Human papillomavirus (HPV) infections are closely associated with anal cancer which is high among human immunodeficiency virus (HIV) infected males. There are no data regarding anal HPV infection and cytological abnormalities in HIV positive males receiving free therapy in the national program. Thus, this cross-sectional study was performed to assess the prevalence and risk factors of anal HPV infection and cytological abnormalities in HIV positive males.

methodsWe screened 126 HIV-positive male patients attending the antiretroviral treatment center (ART) between 2014 and 2015 with anal papanicolaou smear cytology and HPV-DNA testing. HPV-DNA was detected by using polymerase chain reaction (PCR) method with two consensus primer sets E6 and MY09/11 and further analyzed for the presence of various HPV genotype by Sanger sequencing. Risk factors associated with anal cytological abnormalities and HPV infection was analyzed by using univariate and multivariate logistic regression models.

resultsOut of 126, 52 were on antiretroviral therapy. 91% were married to female partners but during the study 48 (38%) gave positive history of anal intercourse with other men. Anal cytology was done in 95 patients, out of which 60 (63.15%) had cytological abnormalities. LSIL (low-grade squamous intraepithelial lesions) was present in 27 (45%), ASCUS (atypical squamous cells of undetermined significance) in 31 (52%) and ASC-H (atypical squamous cells cannot exclude a high-grade squamous intraepithelial lesion) in 2 (3.33%). In multivariate analysis, the risk factors for cytological abnormality were presence of history of anal intercourse (OR, 6.1; 95% CI, 2.0-18.7) and WHO stage III & IV (OR, 2.7; 95% CI, 1.1-7.5). HPV-DNA was detected in 33/119 (27.73%) patients. The most prevalent HPV type in the study was HPV-16 (10.08%), other HPV types detected were 18,31,35,17,66,72,52,68 and 107 (17.65%).

conclusionsHigh prevalence of anal cytological abnormalities in our study suggests that regular anal Pap smear screening should be done in HIV positive males in the ART center.

Indexed as

AdultAIDS-Related Opportunistic InfectionsAnal CanalAnus NeoplasmsCoinfectionCross-Sectional StudiesFemaleGenotypeHIVHIV InfectionsHIV SeropositivityHomosexuality, MaleHuman papillomavirus 16HumansIndiaMaleAnal cancerAnal cytologyHIVHPVIndiaPCR

Identifiers

PMID30587145
PMCPMC6307225
OpenAlexW2905697300

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