ArticleBMC genomics2018
Genetic diversity of Escherichia coli in gut microbiota of patients with Crohn's disease discovered using metagenomic and genomic analyses.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Genetic and Microbial Analysis of Invasiveness for Escherichia coli Strains Associated With Inflammatory Bowel Disease.Cellular and molecular gastroenterology and hepatology · 2025Article
- A single rare σ70 variant establishes a unique gene expression pattern in the E. coli pathobiont LF82.Nucleic acids research · 2024Article
- Evidence for a Causal Role for Escherichia coli Strains Identified as Adherent-Invasive (AIEC) in Intestinal Inflammation.mSphere · 2023Article
- Understanding the Diurnal Oscillation of the Gut Microbiota Using Microbial Culture.Life (Basel, Switzerland) · 2023Article
- Beta-Lactam Antibiotic Resistance Genes in the Microbiome of the Public Transport System of Quito, Ecuador.International journal of environmental research and public health · 2023Article
- Review
- Role of adherent invasiveWorld journal of clinical cases · 2022Review
- Approximation of a Microbiome Composition Shift by a Change in a Single Balance Between Two Groups of Taxa.mSystems · 2022Article
- Strain-Level Metagenomic Data Analysis of Enriched In Vitro and In Silico Spiked Food Samples: Paving the Way towards a Culture-Free Foodborne Outbreak Investigation Using STEC as a Case Study.International journal of molecular sciences · 2020Article
- Development of qPCR platform with probes for quantifying prevalent and biomedically relevant human gut microbial taxa.Molecular and cellular probes · 2020Article
- Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study.Critical care (London, England) · 2020Observational
- Microbiome-Metabolome Signature of Acute Kidney Injury.Metabolites · 2020Article
- Metabolic Phenotypes as Potential Biomarkers for Linking Gut Microbiome With Inflammatory Bowel Diseases.Frontiers in molecular biosciences · 2020Article
- Co-occurrence patterns of bacteria within microbiome of Moscow subway.Computational and structural biotechnology journal · 2020Article
- Shifts in the Human Gut Microbiota Structure Caused by QuadrupleFrontiers in microbiology · 2019Article
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Authors and funding
28 authors.
Funding
Abstract
backgroundCrohn's disease is associated with gut dysbiosis. Independent studies have shown an increase in the abundance of certain bacterial species, particularly Escherichia coli with the adherent-invasive pathotype, in the gut. The role of these species in this disease needs to be elucidated.
methodsWe performed a metagenomic study investigating the gut microbiota of patients with Crohn's disease. A metagenomic reconstruction of the consensus genome content of the species was used to assess the genetic variability.
resultsThe abnormal shifts in the microbial community structures in Crohn's disease were heterogeneous among the patients. The metagenomic data suggested the existence of multiple E. coli strains within individual patients. We discovered that the genetic diversity of the species was high and that only a few samples manifested similarity to the adherent-invasive varieties. The other species demonstrated genetic diversity comparable to that observed in the healthy subjects. Our results were supported by a comparison of the sequenced genomes of isolates from the same microbiota samples and a meta-analysis of published gut metagenomes.
conclusionsThe genomic diversity of Crohn's disease-associated E. coli within and among the patients paves the way towards an understanding of the microbial mechanisms underlying the onset and progression of the Crohn's disease and the development of new strategies for the prevention and treatment of this disease.
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