ArticleMolecules (Basel, Switzerland)2018
Properties of Therapeutic Deep Eutectic Solvents of l-Arginine and Ethambutol for Tuberculosis Treatment.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 68 citations in OpenAlex.
- Advancements in Therapeutic Deep Eutectic Solvents as Multifunctional Transdermal Delivery Systems.Pharmaceutics · 2026Review
- Natural deep eutectic solvents (NaDES): green solvents for pharmaceutical applications and beyond.Green chemistry : an international journal and green chemistry resource : GC · 2025Review
- An Overview on the Role of Ionic Liquids and Deep Eutectic Solvents in Oral Pharmaceuticals.Pharmaceutics · 2025Review
- Pharmaceutical applications of therapeutic deep eutectic systems (THEDES) in maximising drug delivery.Heliyon · 2024Review
- Therapeutic Liquid Eutectic Solvents in Lipid Nanoparticles as Drug Vehicles-A Proof of Concept.International journal of molecular sciences · 2023Article
- Deep Eutectic Solvents Formed by Glycerol and Xylitol, Fructose and Sorbitol: Effect of the Different Sugars in Their Physicochemical Properties.Molecules (Basel, Switzerland) · 2023Article
- Using Natural Deep Eutectic Systems as Alternative Media for Ocular Applications.Pharmaceutics · 2023Article
- Controversy on the toxic nature of deep eutectic solvents and their potential contribution to environmental pollution.Heliyon · 2022Review
- Solids Turn into Liquids-Liquid Eutectic Systems of Pharmaceutics to Improve Drug Solubility.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Therapeutic Deep Eutectic Systems towards the Treatment of Tuberculosis and Colorectal Cancer: Opportunities and Challenges.Molecules (Basel, Switzerland) · 2021Review
- Therapeutic Liquid Formulations Based on Low Transition Temperature Mixtures for the Incorporation of Anti-Inflammatory Drugs.Pharmaceutics · 2021Article
- Molecular Dynamics Studies of Therapeutic Liquid Mixtures and Their Binding to Mycobacteria.Frontiers in pharmacology · 2021Article
- Organic Salts Based on Isoniazid Drug: Synthesis, Bioavailability and Cytotoxicity Studies.Pharmaceutics · 2020Article
- Therapeutic Role of Deep Eutectic Solvents Based on Menthol and Saturated Fatty Acids on Wound Healing.ACS applied bio materials · 2019Article
- Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The treatment for tuberculosis infection usually involves a prolonged regimen of multiple antibacterial drugs, which might lead to various secondary effects. For preventing drug resistance and side-effects of anti-tuberculosis drugs, new methods for improving the bioavailability of APIs were investigated. The strategy proposed consists of the preparation of therapeutic deep eutectic solvents (THEDES), that incorporate l-arginine and ethambutol. The eutectic mixtures were prepared by mixing the components at a certain molar ratio, until a clear liquid solution was formed. The prepared mixtures were characterized by differential scanning calorimetry (DSC), polarized optical microscopy (POM) and nuclear magnetic resonance spectroscopy (¹H and
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Registered trials
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