Bioinspired-Metalloporphyrin Magnetic Nanocomposite as a Reusable Catalyst for Synthesis of Diastereomeric (-)-Isopulegol Epoxide: Anticancer Activity Against Human Osteosarcoma Cells (MG-63).
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 16 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors at 3 institutions in 2 countries.
Lucas D DiasCoimbra Chemistry Centre, CQC, Departament of Chemistry, Faculdade de Ciências e Tecnologia, Universidad de Coimbra, 3004⁻535 Coimbra, Portugal. lucasdanillodias@gmail.com.ORCID 0000-0003-2858-7539
Ana L M Batista de CarvalhoUnidade de I&D Química-Física Molecular, Department of Chemistry, University of Coimbra, 3004⁻535 Coimbra, Portugal. almbc@ci.uc.pt.ORCID 0000-0003-1280-3321
Sara M A PintoCoimbra Chemistry Centre, CQC, Departament of Chemistry, Faculdade de Ciências e Tecnologia, Universidad de Coimbra, 3004⁻535 Coimbra, Portugal. smpinto@qui.uc.pt.ORCID 0000-0003-3817-1182
Gilberto L B AquinoCoimbra Chemistry Centre, CQC, Departament of Chemistry, Faculdade de Ciências e Tecnologia, Universidad de Coimbra, 3004⁻535 Coimbra, Portugal. gilberto.benedito@ueg.br.ORCID 0000-0001-9397-7803
Mário J F CalveteCoimbra Chemistry Centre, CQC, Departament of Chemistry, Faculdade de Ciências e Tecnologia, Universidad de Coimbra, 3004⁻535 Coimbra, Portugal. mcalvete@qui.uc.pt.ORCID 0000-0003-2094-4781
Liane M RossiDepartamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, São Paulo 05508⁻000, Brazil. lrossi@iq.usp.br.
M P M MarquesUnidade de I&D Química-Física Molecular, Department of Chemistry, University of Coimbra, 3004⁻535 Coimbra, Portugal. pmc@ci.uc.pt.
Mariette M PereiraCoimbra Chemistry Centre, CQC, Departament of Chemistry, Faculdade de Ciências e Tecnologia, Universidad de Coimbra, 3004⁻535 Coimbra, Portugal. mmpereira@qui.uc.pt.
University of Coimbra · PTUniversidade de São Paulo · BRUniversidade Estadual de Goiás · BR
Funding
HYALURONAN BIOSYNTHESIS IN PROSTATE CARCINOMAF32CA084619 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SIMPSON, MELANIE A · 2000 to 2002
$98k
Centro2020 ReNATURE - CENTRO-01-0145-FEDER-000007Conselho Nacional de Desenvolvimento Científico e Tecnológico L.D.D. - PhD grant 232620/2014-8/GDEFundação para a Ciência e a Tecnologia Coimbra Chemistry Centre - PEst-OE/QUI/UI0313/2014Fundação para a Ciência e a Tecnologia M.J.F.C. - SFRH/BPD/99698/2014Fundação para a Ciência e a Tecnologia Molecular Physical-Chemistry R&D Unit - UID/MULTI/00070/2013Fundação para a Ciência e a Tecnologia S.M.A.P - SFRH/BPD/84619/2012
6 · The paper itself
Abstract
In the present study, we developed a green epoxidation approach for the synthesis of the diastereomers of (-)-isopulegol benzyl ether epoxide using molecular oxygen as the oxidant and a hybrid manganese(III)-porphyrin magnetic reusable nanocomposite as the catalyst. High activity, selectivity, and stability were obtained, with up to four recycling cycles without the loss of activity and selectivity for epoxide. The anticancer effect of the newly synthesized isopulegol epoxide diastereomers was evaluated on a human osteosarcoma cell line (MG-63); both diastereomers showed similar in vitro potency. The measured IC
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Bioinspired-Metalloporphyrin Magnetic Nanocomposite as a Reusable Catalyst for Synthesis of Diastereomeric (-)-Isopulegol Epoxide: Anticancer Activity Against Human Osteosarcoma Cells (MG-63). · full record | OpenQuestion