Evidence map›Paper›PMID 30586725›Full record

ArticleCirculation2019

Twenty Year Trends and Sex Differences in Young Adults Hospitalized With Acute Myocardial Infarction.

Sameer Arora, George A Stouffer, Anna M Kucharska-Newton, Arman Qamar, Muthiah Vaduganathan, Ambarish Pandey, Deborah Porterfield, Ron Blankstein, Wayne D Rosamond, Deepak L Bhatt and 1 more

Registry-linked trialOpen access · bronzeAbstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05619601 (Gender Differences in Prevention Strategies and Therapeutic Adherence After Acute Myocardial Infarction - GENAMI PREVENTION), which is not on this map. Cited by 373 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
373citing papers in PubMed, 4 pooled it
46.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05619601 completednot on this mapstarted 2023, after this paper: background citation

Gender Differences in Prevention Strategies and Therapeutic Adherence After Acute Myocardial Infarction - GENAMI PREVENTION

Typeobservational_patient_registrySponsorSpanish Society of CardiologyRan2023 to 2026Enrolled530ConditionsGender Differences, Adherence, Medication, Therapeutic Adherence, Type 1 Acute Myocardial Infarction
3 · Its place in the literature

Who cites it

373 citing papers in PubMed, 4 syntheses or guidelines pooled it, 750 citations in OpenAlex.

  1. Pooled it
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  16. Subtypes of Hypertension 2 to 7 Years After First Pregnancy.Hypertension (Dallas, Tex. : 1979) · 2026
    Observational
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313 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sameer AroraDivision of Cardiology, University of North Carolina School of Medicine, Chapel Hill (S.A., G.S., M.C.).
George A StoufferDivision of Cardiology, University of North Carolina School of Medicine, Chapel Hill (S.A., G.S., M.C.).
Anna M Kucharska-NewtonDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill (S.A., A.KN, W.R.).
Arman QamarBrigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, MA (A.Q., M.V, D.L.B.).
Muthiah VaduganathanBrigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, MA (A.Q., M.V, D.L.B.).
Ambarish PandeyDivision of Cardiology, University of Texas Southwestern Medical Center, Dallas (A.P.).
Deborah PorterfieldSocial and Health Organizational Research and Evaluation Program, RTI International, Research Triangle Park, NC (D.P.).
Ron BlanksteinDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.B.).
Wayne D RosamondDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill (S.A., A.KN, W.R.).
Deepak L BhattBrigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, MA (A.Q., M.V, D.L.B.).
Melissa C CaugheyDivision of Cardiology, University of North Carolina School of Medicine, Chapel Hill (S.A., G.S., M.C.).
University of North Carolina at Chapel Hill · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
TRAINING PROGRAM IN CARDIOVASCULAR RESEARCHT32HL007604 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MARK W FEINBERG · 1985 to 2026
$19.0M
Institutional Career Development CoreKL2TR002542 · NCATS · HARVARD MEDICAL SCHOOL · PI BREDELLA, MIRIAM ANTOINETTE, RUTKOVE, SEWARD B. · 2018 to 2022
$8.7M
NCATS NIH HHS KL2 TR002542NCATS NIH HHS UL1 TR001102NHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS T32 HL007604
6 · The paper itself

Abstract

backgroundSex differences are known to exist in the management of older patients presenting with acute myocardial infarction (AMI). Few studies have examined the incidence and risk factors of AMI among young patients, or whether clinical management differs by sex.

methodsThe Atherosclerosis Risk in Communities (ARIC) Surveillance study conducts hospital surveillance of AMI in 4 US communities (MD, MN, MS, and NC). AMI was classified by physician review, using a validated algorithm. Medications and procedures were abstracted from the medical record. Our study population was limited to young patients aged 35 to 54 years.

resultsFrom 1995 to 2014, 28 732 weighted hospitalizations for AMI were sampled among patients aged 35 to 74 years. Of these, 8737 (30%) were young. The annual incidence of AMI hospitalizations increased for young women but decreased for young men. The overall proportion of AMI admissions attributable to young patients steadily increased, from 27% in 1995 to 1999 to 32% in 2010 to 2014 ( P for trend=0.002), with the largest increase observed in young women. History of hypertension (59% to 73%, P for trend<0.0001) and diabetes mellitus (25% to 35%, P for trend<0.0001) also increased among young AMI patients. Compared to young men, young women presenting with AMI were more often black and had a greater comorbidity burden. In adjusted analyses, young women had a lower probability of receiving lipid-lowering therapies (relative risk [RR]=0.87; 95% confidence interval [CI], 0.80-0.94), nonaspirin antiplatelets (RR=0.83; 95% CI, 0.75-0.91), beta blockers (RR=0.96; 95% CI, 0.91-0.99), coronary angiography (RR=0.93; 95% CI, 0.86-0.99) and coronary revascularization (RR = 0.79; 95% CI, 0.71-0.87). However, 1-year all-cause mortality was comparable for women versus men (HR=1.10; 95% CI, 0.83-1.45).

conclusionsThe proportion of AMI hospitalizations attributable to young patients increased from 1995 to 2014 and was especially pronounced among women. History of hypertension and diabetes among young patients admitted with AMI increased over time as well. Compared with young men, young women presenting with AMI had a lower likelihood of receiving guideline-based AMI therapies. A better understanding of factors underlying these changes is needed to improve care of young patients with AMI.

Indexed as

AdultAgedAge DistributionAge FactorsFemaleHealthcare DisparitiesHealth Status DisparitiesHospitalizationHumansIncidenceMaleMiddle AgedMyocardial InfarctionRisk AssessmentRisk FactorsSex Distributionacute myocardial infarctionepidemiologysex differences

Identifiers

PMID30586725
PMCPMC6380926
OpenAlexW2901716735

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.