Trial reportCirculation2019
Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals.
Open access · bronzeAbstract readClinical Trial
In one paragraph
Trial report in Circulation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- LATS1/2-CD38 Metabolic Rewiring Links Senescence to Intraplaque Thrombosis.Circulation research · 2026Article
- RSK1-SRF signaling axis drives fibroblast activation and pulmonary fibrosis: Genetic causality and therapeutic targeting.iScience · 2026Article
- Monocytes Defined by Platelet Interactions and Oxidative Stress Signaling Underlie HIV-Associated Atherosclerosis.Journal of the American Heart Association · 2026Article
- HDL dysfunction: a role in the pathogenesis of cardiometabolic syndrome in chronic HIV infection?Metabolism: clinical and experimental · 2026Review
- Nuclear factor erythroid 2-related factor: potential use as a therapeutic strategy for viral infections.Archives of microbiology · 2026Review
- HIV associated immune aging among people living with HIV: implications for long-term antiretroviral therapy and potential HIV cure interventions in sub-Saharan Africa.Frontiers in immunology · 2026Review
- Monocytes in HIV associated atherosclerosis: A review of pathogenesis and clinical implications.Caspian journal of internal medicine · 2026Review
- Ferroptosis and macrophage efferocytosis in periodontitis: Biological insights and therapeutic advances.Virulence · 2025Review
- Mechanism of Neutrophil p90RSK-Nrf2 Signaling Pathway in Atherosclerosis.Balkan medical journal · 2025Article
- p90RSK modulates inter-and intracellular signaling in kidney diseases.Frontiers in cell and developmental biology · 2025Review
- NRF2 signaling pathway and telomere length in aging and age-related diseases.Molecular and cellular biochemistry · 2024Review
- Potential diagnostic markers shared between non-alcoholic fatty liver disease and atherosclerosis determined by machine learning and bioinformatic analysis.Frontiers in medicine · 2024Article
- Aerobic Exercise Alters the Melanoma Microenvironment and Modulates ERK5 S496 Phosphorylation.Cancer immunology research · 2023Article
- An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis.Circulation research · 2023Article
- Review
- Article
- Article
- Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition.Frontiers in cardiovascular medicine · 2023Article
- Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights.Frontiers in cardiovascular medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 8 institutions in 4 countries.
Meera V SinghDepartments of Microbiology and Immunology (M.V.S., N.E.S., K.J.G., S.B.M.), University of Rochester, NY.
Sivareddy KotlaDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston (S.K., N.-T.L., K.A.K., K.-S.H., Y.W., Y.F., H.T.V., E.M., T.N.T., Y.J.G., Y.T., J.L.M., K.F., J.-i.A.).
Nhat-Tu LeDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston (S.K., N.-T.L., K.A.K., K.-S.H., Y.W., Y.F., H.T.V., E.M., T.N.T., Y.J.G., Y.T., J.L.M., K.F., J.-i.A.).
Kyung Ae KoDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston (S.K., N.-T.L., K.A.K., K.-S.H., Y.W., Y.F., H.T.V., E.M., T.N.T., Y.J.G., Y.T., J.L.M., K.F., J.-i.A.).
Kyung-Sun HeoDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston (S.K., N.-T.L., K.A.K., K.-S.H., Y.W., Y.F., H.T.V., E.M., T.N.T., Y.J.G., Y.T., J.L.M., K.F., J.-i.A.).
Yin WangDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston (S.K., N.-T.L., K.A.K., K.-S.H., Y.W., Y.F., H.T.V., E.M., T.N.T., Y.J.G., Y.T., J.L.M., K.F., J.-i.A.).
Yuka FujiiDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston (S.K., N.-T.L., K.A.K., K.-S.H., Y.W., Y.F., H.T.V., E.M., T.N.T., Y.J.G., Y.T., J.L.M., K.F., J.-i.A.).
Hang Thi VuDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston (S.K., N.-T.L., K.A.K., K.-S.H., Y.W., Y.F., H.T.V., E.M., T.N.T., Y.J.G., Y.T., J.L.M., K.F., J.-i.A.).
Elena McBeathDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston (S.K., N.-T.L., K.A.K., K.-S.H., Y.W., Y.F., H.T.V., E.M., T.N.T., Y.J.G., Y.T., J.L.M., K.F., J.-i.A.).
Tamlyn N ThomasDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston (S.K., N.-T.L., K.A.K., K.-S.H., Y.W., Y.F., H.T.V., E.M., T.N.T., Y.J.G., Y.T., J.L.M., K.F., J.-i.A.).
Young Jin GiDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston (S.K., N.-T.L., K.A.K., K.-S.H., Y.W., Y.F., H.T.V., E.M., T.N.T., Y.J.G., Y.T., J.L.M., K.F., J.-i.A.).
Yunting TaoDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston (S.K., N.-T.L., K.A.K., K.-S.H., Y.W., Y.F., H.T.V., E.M., T.N.T., Y.J.G., Y.T., J.L.M., K.F., J.-i.A.).
Jan L MedinaDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston (S.K., N.-T.L., K.A.K., K.-S.H., Y.W., Y.F., H.T.V., E.M., T.N.T., Y.J.G., Y.T., J.L.M., K.F., J.-i.A.).
Jack TauntonDepartment of Cellular and Molecular Pharmacology, University of California-San Francisco (J.T.).
Nancy CarsonImaging Sciences (N.C., V.D.), University of Rochester, NY.
Vikram DograImaging Sciences (N.C., V.D.), University of Rochester, NY.
Marvin M DoyleyElectrical and Computer Engineering (M.M.D.), University of Rochester, NY.
Alicia TyrellBiostatistics and Computational Biology (A.T., W.L., X.Q.), University of Rochester, NY.
Wang LuBiostatistics and Computational Biology (A.T., W.L., X.Q.), University of Rochester, NY.
Xing QiuBiostatistics and Computational Biology (A.T., W.L., X.Q.), University of Rochester, NY.
Nicole E StirpeDepartments of Microbiology and Immunology (M.V.S., N.E.S., K.J.G., S.B.M.), University of Rochester, NY.
Kathleen J GatesDepartments of Microbiology and Immunology (M.V.S., N.E.S., K.J.G., S.B.M.), University of Rochester, NY.
Christine HurleyMedicine, Infectious Disease (C.H.), University of Rochester, NY.
Keigi FujiwaraDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston (S.K., N.-T.L., K.A.K., K.-S.H., Y.W., Y.F., H.T.V., E.M., T.N.T., Y.J.G., Y.T., J.L.M., K.F., J.-i.A.).
Sanjay B MaggirwarDepartments of Microbiology and Immunology (M.V.S., N.E.S., K.J.G., S.B.M.), University of Rochester, NY.
Giovanni SchifittoNeurology (G.S.), University of Rochester, NY.
Jun-Ichi AbeDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston (S.K., N.-T.L., K.A.K., K.-S.H., Y.W., Y.F., H.T.V., E.M., T.N.T., Y.J.G., Y.T., J.L.M., K.F., J.-i.A.).
Norwegian Womens Public Health Association · NOUniversity of Rochester · USHouston Methodist · USChungnam National University · KRMVN University · INQi2 · USUniversity of California, San Francisco · USVeer Kunwar Singh University · IN
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MVirology/Immunology CoreP30AI078498 · NIAID · UNIVERSITY OF ROCHESTER · PI DEWHURST, STEPHEN · 2008 to 2018
$14.6MPlatelet-mediated neuroinflammatory response to HIVR01NS066801 · NINDS · UNIVERSITY OF ROCHESTER · PI MAGGIRWAR, SANJAY B. · 2010 to 2020
$3.9MPAR 13-233 cART accelerates vascular aging in HIV infected subjectsR01HL123346 · NHLBI · UNIVERSITY OF ROCHESTER · PI ABE, JUN-ICHI, MAGGIRWAR, SANJAY B. · 2014 to 2018
$3.7MRole of Myeloid Cells in Cerebrovascular Permeability and Reactivity in Older HIV Infected IndividualsR01AG054328 · NIA · UNIVERSITY OF ROCHESTER · PI MAGGIRWAR, SANJAY B., SCHIFITTO, GIOVANNI · 2017 to 2021
$3.5MInflammatory mechanisms associated with HIV-1 dementiaR01NS054578 · NINDS · UNIVERSITY OF ROCHESTER · PI MAGGIRWAR, SANJAY B. · 2006 to 2016
$3.5MPathological flow-induced endothelial damage and plaque erosionR01HL149303 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ABE, JUN-ICHI, COOKE, JOHN P · 2019 to 2022
$3.2MChronic Exposure to cART Predispose Older HIV Infected Individuals to CNS Injury?R01MH099921 · NIMH · UNIVERSITY OF ROCHESTER · PI SCHIFITTO, GIOVANNI · 2013 to 2017
$3.0MRole of tetherin in HIV-associated thromsosisR01HL128155 · NHLBI · UNIVERSITY OF ROCHESTER · PI MAGGIRWAR, SANJAY B. · 2015 to 2018
$2.2MNovel mechanisms of platelet modified monocyte phenotypeR01HL141106 · NHLBI · UNIVERSITY OF ROCHESTER · PI MORRELL, CRAIG N · 2018 to 2021
$2.2MA Novel Role for MAGI1 in regulating non-canonical LATS signaling and atherosclerotic plaque formationR01HL134740 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LE, NHAT-TU · 2017 to 2021
$2.0MDisturbed flow-induced TERF2IP post-translational modifications and atherosclerosis.R01HL130193 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ABE, JUN-ICHI · 2016 to 2019
$2.0MNCI NIH HHS P30 CA016672NHLBI NIH HHS R01 HL118462NHLBI NIH HHS R01 HL123346NHLBI NIH HHS R01 HL128155NHLBI NIH HHS R01 HL130193NHLBI NIH HHS R01 HL134740NHLBI NIH HHS R01 HL141106NHLBI NIH HHS R01 HL149303NIAID NIH HHS P30 AI078498NIA NIH HHS R01 AG054328NIMH NIH HHS R01 MH099921NINDS NIH HHS R01 NS054578NINDS NIH HHS R01 NS066801
Abstract
backgroundThe incidence of cardiovascular disease is higher in HIV-positive (HIV
methodsPeripheral whole blood from cART-treated HIV
resultsMonocytes from HIV
conclusionscART increased monocyte/macrophage sensitivity to reactive oxygen species- in HIV
Indexed as
Cellular SenescenceHIV-1Oxidative StressAnimalsAnti-Retroviral AgentsFemaleHIV SeropositivityHumansMacrophagesMaleMiceNF-E2-Related Factor 2Protein Kinase InhibitorsRibosomal Protein S6 Kinases, 90-kDaAnti-Retroviral AgentsNFE2L2 protein, humanNfe2l2 protein, mouseNF-E2-Related Factor 2Protein Kinase InhibitorsRibosomal Protein S6 Kinases, 90-kDaantioxidantsatherosclerosisHIVreactive oxygen speciessenescencetelomere
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.