Evidence map›Paper›PMID 30586717›Full record

ArticleCirculation2019

Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation.

Maximilian Mauler, Nadine Herr, Claudia Schoenichen, Thilo Witsch, Timoteo Marchini, Carmen Härdtner, Christoph Koentges, Korbinian Kienle, Véronique Ollivier, Maximilian Schell and 14 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 165 citations in OpenAlex.

  1. Article
  2. Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  18. Neuroimmune pathophysiology of long COVID.Psychiatry and clinical neurosciences · 2025
    Review
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  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 7 institutions in 4 countries.

Maximilian MaulerFaculty of Biology (M.M., K.K.), University of Freiburg, Germany.
Nadine HerrFaculty of Medicine (M.M., N.H., C.S., T.W., T.M., C.H., C.K., M.S., L.D., C.W., D.S., C.N., H.B., D.W., C.B., I.H., D.D.), University of Freiburg, Germany.
Claudia SchoenichenFaculty of Medicine (M.M., N.H., C.S., T.W., T.M., C.H., C.K., M.S., L.D., C.W., D.S., C.N., H.B., D.W., C.B., I.H., D.D.), University of Freiburg, Germany.
Thilo WitschFaculty of Medicine (M.M., N.H., C.S., T.W., T.M., C.H., C.K., M.S., L.D., C.W., D.S., C.N., H.B., D.W., C.B., I.H., D.D.), University of Freiburg, Germany.
Timoteo MarchiniFaculty of Medicine (M.M., N.H., C.S., T.W., T.M., C.H., C.K., M.S., L.D., C.W., D.S., C.N., H.B., D.W., C.B., I.H., D.D.), University of Freiburg, Germany.
Carmen HärdtnerFaculty of Medicine (M.M., N.H., C.S., T.W., T.M., C.H., C.K., M.S., L.D., C.W., D.S., C.N., H.B., D.W., C.B., I.H., D.D.), University of Freiburg, Germany.
Christoph KoentgesFaculty of Medicine (M.M., N.H., C.S., T.W., T.M., C.H., C.K., M.S., L.D., C.W., D.S., C.N., H.B., D.W., C.B., I.H., D.D.), University of Freiburg, Germany.
Korbinian KienleFaculty of Biology (M.M., K.K.), University of Freiburg, Germany.
Véronique OllivierINSERM Unit 1148, University Paris Diderot (V.O., B.H-T-N.), France.
Maximilian SchellFaculty of Medicine (M.M., N.H., C.S., T.W., T.M., C.H., C.K., M.S., L.D., C.W., D.S., C.N., H.B., D.W., C.B., I.H., D.D.), University of Freiburg, Germany.
Ludwig DornerFaculty of Medicine (M.M., N.H., C.S., T.W., T.M., C.H., C.K., M.S., L.D., C.W., D.S., C.N., H.B., D.W., C.B., I.H., D.D.), University of Freiburg, Germany.
Christopher WippelFaculty of Medicine (M.M., N.H., C.S., T.W., T.M., C.H., C.K., M.S., L.D., C.W., D.S., C.N., H.B., D.W., C.B., I.H., D.D.), University of Freiburg, Germany.
Daniela StallmannFaculty of Medicine (M.M., N.H., C.S., T.W., T.M., C.H., C.K., M.S., L.D., C.W., D.S., C.N., H.B., D.W., C.B., I.H., D.D.), University of Freiburg, Germany.
Claus NormannFaculty of Medicine (M.M., N.H., C.S., T.W., T.M., C.H., C.K., M.S., L.D., C.W., D.S., C.N., H.B., D.W., C.B., I.H., D.D.), University of Freiburg, Germany.
Heiko BuggerFaculty of Medicine (M.M., N.H., C.S., T.W., T.M., C.H., C.K., M.S., L.D., C.W., D.S., C.N., H.B., D.W., C.B., I.H., D.D.), University of Freiburg, Germany.
Paul WaltherCentral Facility for Electron Microscopy, Ulm University; Ulm, Germany (P.W.).
Dennis WolfFaculty of Medicine (M.M., N.H., C.S., T.W., T.M., C.H., C.K., M.S., L.D., C.W., D.S., C.N., H.B., D.W., C.B., I.H., D.D.), University of Freiburg, Germany.
Ingo AhrensDepartment of Cardiology and Angiology I, Heart Center (M.M., N.H., C.S., T.M., C.H., C.K., M.S., L.D., C.W., D.S., H.B., D.W., I.A., C.B., I.H., D.D.), University of Freiburg, Germany.
Tim LämmermannMax Planck Institute of Immunobiology and Epigenetics, Group Immune Cell Dynamics (K.K., T.L.), Germany.
Benoît Ho-Tin-NoéINSERM Unit 1148, University Paris Diderot (V.O., B.H-T-N.), France.
Klaus LeyLa Jolla Institute for Allergy and Immunology, La Jolla, CA (D.W., K.L.).
Christoph BodeFaculty of Medicine (M.M., N.H., C.S., T.W., T.M., C.H., C.K., M.S., L.D., C.W., D.S., C.N., H.B., D.W., C.B., I.H., D.D.), University of Freiburg, Germany.
Ingo HilgendorfFaculty of Medicine (M.M., N.H., C.S., T.W., T.M., C.H., C.K., M.S., L.D., C.W., D.S., C.N., H.B., D.W., C.B., I.H., D.D.), University of Freiburg, Germany.
Daniel DuerschmiedFaculty of Medicine (M.M., N.H., C.S., T.W., T.M., C.H., C.K., M.S., L.D., C.W., D.S., C.N., H.B., D.W., C.B., I.H., D.D.), University of Freiburg, Germany.
Mahindra and Mahindra Limited (India) · INInserm · FRLa Jolla Institute for Immunology · USUniversity of Freiburg · DEMax Planck Institute of Immunobiology and Epigenetics · DEUniversität Ulm · DEUniversity Medical Center Freiburg · DE

Funding

Myeloid cell interactions with T cells in atherosclerosisR01HL115232 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2012 to 2018
$3.2M
NHLBI NIH HHS R01 HL115232
6 · The paper itself

Abstract

backgroundPlatelets store large amounts of serotonin that they release during thrombus formation or acute inflammation. This facilitates hemostasis and modulates the inflammatory response.

methodsInfarct size, heart function, and inflammatory cell composition were analyzed in mouse models of myocardial reperfusion injury with genetic and pharmacological depletion of platelet serotonin. These studies were complemented by in vitro serotonin stimulation assays of platelets and leukocytes in mice and men, and by measuring plasma serotonin levels and leukocyte activation in patients with acute coronary syndrome.

resultsPlatelet-derived serotonin induced neutrophil degranulation with release of myeloperoxidase and hydrogen peroxide (H

conclusionsTaken together, we identify serotonin as a potent therapeutic target in neutrophil-dependent thromboinflammation during myocardial reperfusion injury.

Indexed as

Cell DegranulationAcute Coronary SyndromeAnimalsBlood PlateletsCase-Control StudiesCD11b AntigenDisease Models, AnimalHumansHydrogen PeroxideMice, Inbred C57BLMice, KnockoutMyocardial InfarctionMyocardial Reperfusion InjuryMyocardiumNeutrophilsPeroxidaseCD11b AntigenHydrogen PeroxideItgam protein, mousePeroxidaseSerotoninTph1 protein, mouseTryptophan Hydroxylaseblood plateletsinflammationintegrinsneutrophilsreactive oxygen speciesreperfusion injuryserotonin

Identifiers

PMID30586717
PMCPMC6370531
OpenAlexW2898232550

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.