Evidence map›Paper›PMID 30586638›Full record

ReviewNeuroscience letters2019

Central nervous system circuits that control body temperature.

Christopher J Madden, Shaun F Morrison

Abstract readReview
In one paragraph

Review in Neuroscience letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 162 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Neural Control of Homeothermy, Torpor, and Hibernation.Annual review of neuroscience · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Infrared thermography in clinical practice: a literature review.European journal of medical research · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Earlier vasoconstriction in females than males with matched body size and composition in neutral-cool conditions.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher J MaddenDepartment of Neurological Surgery, Oregon Health & Science University, Portland, OR, United States. Electronic address: maddench@ohsu.edu.
Shaun F MorrisonDepartment of Neurological Surgery, Oregon Health & Science University, Portland, OR, United States.
Oregon Health & Science University · US

Funding

Central Sympathetic Regulation of Thermogenesis in FeverR01NS040987 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI MORRISON, SHAUN F · 2001 to 2013
$3.7M
CENTRAL REGULATION OF SYMPATHETIC ACTIVITY TO BROWN FATR01DK057838 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI MORRISON, SHAUN F · 2001 to 2010
$2.1M
Neural mechanisms in high fat diet impairment of brown adipose tissue activityR01DK112198 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI MADDEN, CHRISTOPHER J · 2018 to 2022
$2.1M
Central inhibitory regulation of brown adipose thermogenesisR01NS091066 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI MORRISON, SHAUN F · 2015 to 2018
$1.3M
Central neural circuits involved in the febrile responseF32DK065401 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI MADDEN, CHRISTOPHER J · 2004 to 2006
$149k
NIDDK NIH HHS F32 DK065401NIDDK NIH HHS R01 DK057838NIDDK NIH HHS R01 DK112198NINDS NIH HHS R01 NS040987NINDS NIH HHS R01 NS091066
6 · The paper itself

Abstract

Maintenance of mammalian core body temperature within a narrow range is a fundamental homeostatic process to optimize cellular and tissue function, and to improve survival in adverse thermal environments. Body temperature is maintained during a broad range of environmental and physiological challenges by central nervous system circuits that process thermal afferent inputs from the skin and the body core to control the activity of thermoeffectors. These include thermoregulatory behaviors, cutaneous vasomotion (vasoconstriction and, in humans, active vasodilation), thermogenesis (shivering and brown adipose tissue), evaporative heat loss (salivary spreading in rodents, and human sweating). This review provides an overview of the central nervous system circuits for thermoregulatory reflex regulation of thermoeffectors.

Indexed as

AnimalsBody TemperatureBody Temperature RegulationHumansNeural PathwaysShiveringSkin TemperatureThermogenesisBrown adipose tissueCutaneous vasomotionSaliva secretionShiveringSweatingThermoregulation

Identifiers

PMID30586638
PMCPMC6397692
OpenAlexW2906035186

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.