ArticlePloS one2018
Heart diseases and echocardiography in rural Tanzania: Occurrence, characteristics, and etiologies of underappreciated cardiac pathologies.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06704633 (Health Status After Switching Angiotensin-converting Enzyme Inhibitors or Angiotensin Receptor Blockers to Sacubitril-valsartan in Patients With Heart Failure With Reduced Ejection Fraction From Rural Tanzania), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Health Status After Switching Angiotensin-converting Enzyme Inhibitors or Angiotensin Receptor Blockers to Sacubitril-valsartan in Patients With Heart Failure With Reduced Ejection Fraction From Rural Tanzania: An Interventional Study
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Prevalence of congenital septal defects among congenital heart defect patients in East Africa: A systematic review and meta-analysis.PloS one · 2021Pooled it
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- Phenotypic profile and predictors of adverse outcomes during paediatric cardiac catheterisation at an academic hospital, South Africa.Frontiers in pediatrics · 2026Article
- Prolonged length of hospital stay and its associated factors among patients admitted with heart failure: a cross-sectional study in Dar Es Salaam, Tanzania.BMC cardiovascular disorders · 2025Article
- The quality of life of children with heart disease in Tanzania: a single center study.BMC pediatrics · 2025Article
- Transformation of Cardiology and Cardiothoracic Services at Benjamin Mkapa Hospital, Tanzania: Findings and Experiences from 1,313 Cardiovascular Procedures in Five Years.Global heart · 2025Article
- Assessment of the financial gaps in cardiothoracic surgery in Africa.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- Recovery of left ventricular systolic function in peripartum cardiomyopathy: an observational study from rural Tanzania.BMC cardiovascular disorders · 2024Observational
- Use of a Handheld Ultrasonographic Device to Identify Heart Failure and Pulmonary Disease in Rural Africa.JAMA network open · 2024Article
- Knowledge of non-communicable diseases and access to healthcare services among adults before and during COVID-19 pandemic in rural Tanzania.Frontiers in public health · 2024Article
- A reflection of Africa's cardiac surgery capacity to manage congenital heart defects: a perspective.Annals of medicine and surgery (2012) · 2023Article
- Spectrum of cardiac diseases among young and older adults defined by echocardiography at Jakaya Kikwete Cardiac Institute: A prospective cross-sectional study.BMC cardiovascular disorders · 2023Article
- Management, clinical outcomes, and its predictors among heart failure patients admitted to tertiary care hospitals in Ethiopia: prospective observational study.BMC cardiovascular disorders · 2023Observational
- Article
- Ultrasonographic findings in patients with abdominal symptoms or trauma presenting to an emergency room in rural Tanzania.PloS one · 2022Observational
- Developing a Sustainable Cardiovascular Disease Research Strategy in Tanzania Through Training: Leveraging From the East African Centre of Excellence in Cardiovascular Sciences Project.Frontiers in cardiovascular medicine · 2022Review
- Spectrum of cardiovascular diseases at a referral tertiary care hospital in Somalia, Mogadishu: an echocardiographic study.BMC cardiovascular disorders · 2021Observational
- Improving anticoagulation in sub-Saharan Africa: What are the challenges and how can we overcome them?British journal of clinical pharmacology · 2021Review
- Comparison of Predicted Cardiovascular Risk Profiles by Different CVD Risk-Scoring Algorithms between HIV-1-Infected and Uninfected Adults: A Cross-Sectional Study in Tanzania.HIV/AIDS (Auckland, N.Z.) · 2021Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about heart diseases and their treatment in rural sub-Saharan Africa. This study aimed to describe the occurrence, characteristics, and etiologies of heart diseases, and the medication taken before and prescribed after echocardiography in a rural referral Hospital in Tanzania.
methodsThis prospective descriptive cohort study included all adults and children referred for echocardiography. Clinical and echocardiographic data were collated for analysis.
resultsFrom December 2015 to October 2017, a total of 1'243 echocardiograms were performed. A total of 815 adults and 59 children ≤15 years had abnormal echocardiographic findings; in adults 537/815 (66%) had hypertension, with 230/537(43%) on antihypertensive drugs, and 506/815 (62%) were not on regular cardiac medication; 346/815 (42%) had severe eccentric or concentric left ventricular hypertrophy, and 182/815 (22%) had severe systolic heart failure. Only 44% demonstrated normal left ventricular systolic function. The most frequent heart diseases were hypertensive heart disease (41%), valvular heart disease (18%), coronary heart disease (18%), peripartum cardiomyopathy (7%), and other non-hypertensive dilated cardiomyopathies (6%) in adults, and congenital heart disease (34%) in children. Following echocardiography, 802/815 (98%) adults and 40/59 (68%) children had an indication for cardiac medication, 70/815 (9%) and 2/59 (3%) for oral anticoagulation, and 35/815 (4%) and 23/59 (39%) for cardiac surgery, respectively.
conclusionHypertension is the leading etiology of heart diseases in rural Tanzania. Most patients present with advanced stages of heart disease, and the majority are not treated before echocardiography. There is an urgent need for increased awareness, expertise and infrastructure to detect and treat hypertension and heart failure in rural Africa.
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