ArticlePloS one2018
Injury-induced cold sensitization in Drosophila larvae involves behavioral shifts that require the TRP channel Brv1.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Neural substrates of cold nociception ineLife · 2025Article
- Cold-Sensing TRP Channels and Temperature Preference Modulate Ovarian Development in the Model OrganismInternational journal of molecular sciences · 2025Article
- Cold-Temperature Coding with Bursting and Spiking Based on TRP Channel Dynamics inInternational journal of molecular sciences · 2023Article
- Nociception in fruit fly larvae.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Exaptation and Evolutionary Adaptation in Nociceptor Mechanisms Driving Persistent Pain.Brain, behavior and evolution · 2023Review
- Temperature sensitivity and temperature response across development in theFrontiers in molecular neuroscience · 2023Article
- Transient and Steady-State Properties ofFrontiers in cellular neuroscience · 2022Article
- Modality specific roles for metabotropic GABAergic signaling and calcium induced calcium release mechanisms in regulating cold nociception.Frontiers in molecular neuroscience · 2022Article
- Identification of a neural basis for cold acclimation iniScience · 2021Article
- From wound response to repair - lessons from C. elegans.Cell regeneration (London, England) · 2021Review
- An Improved Assay and Tools for Measuring Mechanical Nociception in Drosophila Larvae.Journal of visualized experiments : JoVE · 2020Article
- Transient receptor potential channels: current perspectives on evolution, structure, function and nomenclature.Proceedings. Biological sciences · 2020Article
- An assay for chemical nociception inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- PeripheralPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Maintenance of cell type-specific connectivity and circuit function requires Tao kinase.Nature communications · 2019Article
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Authors and funding
4 authors.
Funding
Abstract
Nociceptive sensitization involves an increase in responsiveness of pain sensing neurons to sensory stimuli, typically through the lowering of their nociceptive threshold. Nociceptive sensitization is common following tissue damage, inflammation, and disease and serves to protect the affected area while it heals. Organisms can become sensitized to a range of noxious and innocuous stimuli, including thermal stimuli. The basic mechanisms underlying sensitization to warm or painfully hot stimuli have begun to be elucidated, however, sensitization to cold is not well understood. Here, we develop a Drosophila assay to study cold sensitization after UV-induced epidermal damage in larvae. Larvae respond to acute cold stimuli with a set of unique behaviors that include a contraction of the head and tail (CT) or a raising of the head and tail into a U-Shape (US). Under baseline, non-injured conditions larvae primarily produce a CT response to an acute cold (10°C) stimulus, however, we show that cold-evoked responses shift following tissue damage: CT responses decrease, US responses increase and some larvae exhibit a lateral body roll (BR) that is typically only observed in response to high temperature and noxious mechanical stimuli. At the cellular level, class III neurons are required for the decrease in CT, chordotonal neurons are required for the increase in US, and chordotonal and class IV neurons are required for the appearance of BR responses after UV. At the molecular level, we found that the transient receptor potential (TRP) channel brivido-1 (brv1) is required for these behavioral shifts. Our Drosophila model will allow us to precisely identify the genes and circuits involved in cold nociceptive sensitization.
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