Evidence map›Paper›PMID 30586294›Full record

ArticleAnalytical chemistry2019

Peak Annotation and Verification Engine for Untargeted LC-MS Metabolomics.

Lin Wang, Xi Xing, Li Chen, Lifeng Yang, Xiaoyang Su, Herschel Rabitz, Wenyun Lu, Joshua D Rabinowitz

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 129 citations in OpenAlex.

  1. Trial
  2. Tracing NADCell reports · 2026
    Article
  3. Article
  4. Leveraging 13C-Labeling to Assign Molecular Formulas to Unknown Yeast Metabolites.Journal of the American Society for Mass Spectrometry · 2026
    Article
  5. Assessing the metabolomics "dark matter" by a detectable khipu model.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Urinary metabolome dynamics inMetabolomics : Official journal of the Metabolomic Society · 2025
    Article
  15. Review
  16. Article
  17. NADJournal of neuroinflammation · 2025
    Article
  18. Article
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lin WangLewis Sigler Institute for Integrative Genomics , Princeton University , Princeton , New Jersey 08544 , United States.
Xi XingLewis Sigler Institute for Integrative Genomics , Princeton University , Princeton , New Jersey 08544 , United States.
Li ChenLewis Sigler Institute for Integrative Genomics , Princeton University , Princeton , New Jersey 08544 , United States.
Lifeng YangLewis Sigler Institute for Integrative Genomics , Princeton University , Princeton , New Jersey 08544 , United States.
Xiaoyang SuLewis Sigler Institute for Integrative Genomics , Princeton University , Princeton , New Jersey 08544 , United States.ORCID 0000-0001-8081-1396
Herschel RabitzDepartment of Chemistry , Princeton University , Princeton , New Jersey 08544 , United States.ORCID 0000-0002-4433-6142
Wenyun LuLewis Sigler Institute for Integrative Genomics , Princeton University , Princeton , New Jersey 08544 , United States.
Joshua D RabinowitzLewis Sigler Institute for Integrative Genomics , Princeton University , Princeton , New Jersey 08544 , United States.ORCID 0000-0002-1247-4727
Princeton University · USRutgers, The State University of New Jersey · US

Funding

TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5M
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Patrick Seale · 1986 to 2026
$48.3M
Tumor cell metabolism in actionR01CA163591 · NCI · RUTGERS, THE STATE UNIV OF N.J. · PI JOSHUA D RABINOWITZ, Eileen P. White · 2012 to 2026
$7.0M
Metabolism in Action: Quantitative Fluxes in MammalsDP1DK113643 · NIDDK · PRINCETON UNIVERSITY · PI RABINOWITZ, JOSHUA D · 2016 to 2020
$5.7M
Revealing cancer metabolism via mass spectrometry and isotope tracersR50CA211437 · NCI · PRINCETON UNIVERSITY · PI Wenyun Lu · 2016 to 2026
$1.3M
NCI NIH HHS P30 CA072720NCI NIH HHS R01 CA163591NCI NIH HHS R50 CA211437NIDDK NIH HHS DP1 DK113643NIDDK NIH HHS P30 DK019525
6 · The paper itself

Abstract

Untargeted metabolomics can detect more than 10 000 peaks in a single LC-MS run. The correspondence between these peaks and metabolites, however, remains unclear. Here, we introduce a Peak Annotation and Verification Engine (PAVE) for annotating untargeted microbial metabolomics data. The workflow involves growing cells in

Indexed as

MetabolomicsAlgorithmsChromatography, LiquidDatabases, FactualEscherichia coliIsotope LabelingSaccharomyces cerevisiaeTandem Mass Spectrometry

Identifiers

PMID30586294
PMCPMC6501219
OpenAlexW2906160137

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.