ArticleASAIO journal (American Society for Artificial Internal Organs : 1992)2020
Inflammatory Effects of Blood-Air Interface in a Porcine Cardiopulmonary Bypass Model.
Article in ASAIO journal (American Society for Artificial Internal Organs : 1992), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Beyond preservation: future machine perfusion for liver assessment and repair.Nature reviews. Gastroenterology & hepatology · 2025Review
- Recovery model for minimally invasive central cannulation, cardiopulmonary bypass, and cardioplegic arrest in quadrupeds.Perfusion · 2025Article
- Initial experience and outcomes with a hybrid extracorporeal membrane oxygenation and cardiopulmonary bypass circuit for lung transplantation.JTCVS open · 2023Article
- Effects of extracorporeal circulation with different time on platelet count after cardiac surgery: a retrospective study based on medical records.Scientific reports · 2023Article
- Turbulence in surgical suction heads as detected by MRI.The journal of extra-corporeal technology · 2023Article
- Nitric Oxide on Extracorporeal Life Support-Circuit Modifications for a Safe Therapy.The journal of extra-corporeal technology · 2022Article
- Article
- Dialysis-Induced Cardiovascular and Multiorgan Morbidity.Kidney international reports · 2020Review
- Nitric Oxide Attenuates the Inflammatory Effects of Air During Extracorporeal Circulation.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Cardiopulmonary bypass (CPB) causes a systemic inflammatory response syndrome (SIRS) associated with multiorgan injury. A model was developed to test whether a blood-air interface (BAI) in the CPB circuit causes blood element activation and inflammation. Ten healthy swine were placed on partial CPB for 2 hours via the cervical vessels and monitored for 96 hours postoperatively. Five pigs (control group) had minimal air exposure in the circuit, while five were exposed to a BAI simulating cardiotomy suction. There were no significant differences in bypass flow or hemodynamics between the groups. In the BAI group, there was an increase in hemolysis after bypass (plasma-free hemoglobin 5.27 ± 1.2 vs. 0.94 ± 0.8 mg/dl; p = 0.01), more aggressive platelet consumption (28% vs. 83% of baseline; p = 0.009), leukocyte consumption (71% vs. 107% of baseline; p = 0.02), and increased granulocyte CD11b expression (409% vs. 106% of baseline; p = 0.009). These data suggest the inflammatory pattern responsible for the CPB-SIRS phenomenon may be driven by blood-air interaction. Future efforts should focus on BAI-associated mechanisms for minimizing blood trauma and inflammation during CPB.
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Registered trials
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