Evidence map›Paper›PMID 30585753›Full record

ReviewExpert review of vaccines2019

Current perspectives in assessing humoral immunity after measles vaccination.

Iana H Haralambieva, Richard B Kennedy, Inna G Ovsyannikova, Daniel J Schaid, Gregory A Poland

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of vaccines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 58 citations in OpenAlex.

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  15. mRNA-Based Vaccines and Mode of Action.Current topics in microbiology and immunology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Iana H Haralambievaa Mayo Clinic Vaccine Research Group , Mayo Clinic , Rochester , MN , USA.
Richard B Kennedya Mayo Clinic Vaccine Research Group , Mayo Clinic , Rochester , MN , USA.
Inna G Ovsyannikovaa Mayo Clinic Vaccine Research Group , Mayo Clinic , Rochester , MN , USA.
Daniel J Schaida Mayo Clinic Vaccine Research Group , Mayo Clinic , Rochester , MN , USA.
Gregory A Polanda Mayo Clinic Vaccine Research Group , Mayo Clinic , Rochester , MN , USA.
Mayo Clinic in Florida · US

Funding

Bioinformatics Approach to Influenza A/H1N1 Vaccine Immune ProfilingU01AI089859 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 2010 to 2015
$33.8M
The Immunogenetics of Measles ImmunityR01AI033144 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 1993 to 2022
$8.1M
Immunogenetic Mechanisms of Vaccine ResponseR37AI048793 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 2011 to 2020
$5.4M
IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSER01AI048793 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 2001 to 2010
$4.3M
Systems Biology of Mumps Vaccine ResponseR01AI138965 · NIAID · MAYO CLINIC ROCHESTER · PI KENNEDY, RICHARD B · 2018 to 2022
$3.9M
Understanding measles vaccine failure (and success) in Southern IndiaR01AI121054 · NIAID · MAYO CLINIC ROCHESTER · PI JACOB, JOSHY, KENNEDY, RICHARD B · 2017 to 2021
$3.8M
Genetic Markers of Long-Term Mumps Vaccine ImmunityR01AI127365 · NIAID · MAYO CLINIC ROCHESTER · PI KENNEDY, RICHARD B · 2016 to 2020
$3.6M
NIAID NIH HHS R01 AI033144NIAID NIH HHS R01 AI048793NIAID NIH HHS R01 AI121054NIAID NIH HHS R01 AI127365NIAID NIH HHS R01 AI138965NIAID NIH HHS R37 AI048793NIAID NIH HHS U01 AI089859
6 · The paper itself

Abstract

introductionRepeated measles outbreaks in countries with relatively high vaccine coverage are mainly due to failure to vaccinate and importation; however, cases in immunized individuals exist raising questions about suboptimal measles vaccine-induced humoral immunity and/or waning immunity in a low measles-exposure environment. AREAS COVERED: The plaque reduction neutralization measurement of functional measles-specific antibodies correlates with protection is the gold standard in measles serology, but it does not assess cellular-immune or other parameters that may be associated with durable and/or protective immunity after vaccination. Additional correlates of protection and long-term immunity and new determinants/signatures of vaccine responsiveness such as specific CD46 and IFI44L genetic variants associated with neutralizing antibody titers after measles vaccination are under investigation. Current and future systems biology studies, coupled with new technology/assays and analytical approaches, will lead to an increasingly sophisticated understanding of measles vaccine-induced humoral immunity and will identify 'signatures' of protective and durable immune responses. EXPERT OPINION: This will translate into the development of highly predictive assays of measles vaccine efficacy, effectiveness, and durability for prospective identification of potential low/non-responders and susceptible individuals who require additional vaccine doses. Such new advances may drive insights into the development of new/improved vaccine formulations and delivery systems.

Indexed as

Immunity, HumoralAntibodies, NeutralizingAntibodies, ViralDisease OutbreaksHumansMeaslesMeasles VaccineVaccinationVaccination CoverageAntibodies, NeutralizingAntibodies, ViralMeasles Vaccineantibodygene expressiongene polymorphismsgenetic association studiesgenetic variationhumoralimmunityMeaslesmeasles-mumps-rubella vaccinemeasles vaccinesystems biology

Identifiers

PMID30585753
PMCPMC6413513
OpenAlexW2906261488

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.