Evidence map›Paper›PMID 30585741›Full record

ArticleJournal of endourology2019

Simulation of Laser Lithotripsy-Induced Heating in the Urinary Tract.

Adam D Maxwell, Brian MacConaghy, Jonathan D Harper, Ali H Aldoukhi, Timothy L Hall, William W Roberts

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of endourology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 4 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.

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  17. Turning up the HEAT Surgical simulation of the Moses 2.0 laser in an anatomic model.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Adam D Maxwell1 Department of Urology, University of Washington School of Medicine, Seattle, Washington.
Brian MacConaghy2 Applied Physics Laboratory, University of Washington, Seattle, Washington.
Jonathan D Harper1 Department of Urology, University of Washington School of Medicine, Seattle, Washington.
Ali H Aldoukhi3 Department of Urology, University of Michigan, Ann Arbor, Michigan.
Timothy L Hall4 Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.
William W Roberts3 Department of Urology, University of Michigan, Ann Arbor, Michigan.
University of Michigan–Ann Arbor · USUniversity of Washington Applied Physics Laboratory · USUniversity of Washington · US

Funding

Noninvasive fragmentation of urinary calculi with focused ultrasound burstsK01DK104854 · NIDDK · UNIVERSITY OF WASHINGTON · PI MAXWELL, ADAM DOUGLAS · 2015 to 2019
$686k
NIDDK NIH HHS K01 DK104854
6 · The paper itself

Abstract

purposeHolmium laser lithotripsy is a common modality used to fragment urinary stones during ureteroscopy. Laser energy deposited during activation produces heat and potentially causes thermal bioeffects. We aimed to characterize laser-induced heating through a computational simulation. MATERIALS AND

methodsA finite-element model was developed and used to estimate temperature in the urinary tract. Axisymmetric models of laser lithotripsy in a renal calyx, the renal pelvis, and proximal ureter were created. Heat generation by laser and heat transfer were simulated under different laser powers between 5 and 40 W. Irrigation fluid flow was introduced at rates between 0 and 40 mL/min. The model was validated by comparison with previous in vitro temperature data in a test tube, then used to calculate heating and thermal dose in the three tissue models.

resultsSimulated temperature rises agreed well with most in vitro experimental measurements. In tissue models, temperature rises depended strongly on laser power and irrigation rate, and to a lesser extent on location. Injurious temperatures were reached for 5-40 W laser power without irrigation, >10 W with 5 mL/min irrigation, 40 W with 15 mL/min irrigation, and were not found at 40 mL/min irrigation. Tissue injury volumes up to 2.3 cm

conclusionsThe results suggest a numerical model can accurately simulate the thermal profile of laser lithotripsy. Laser heating is strongly dependent on parameters and may cause a substantial temperature rise in the fluid in the urinary tract and surrounding tissue under clinically relevant conditions.

Indexed as

Hot TemperatureKidney PelvisUreterComputer SimulationHumansKidney CalculiLasers, Solid-StateLithotripsy, LaserTemperatureUreteroscopylaser lithotripsyureteroscopyurinary stone

Identifiers

PMID30585741
PMCPMC6388709
OpenAlexW2906649342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.