Evidence map›Paper›PMID 30585697›Full record

ArticleThoracic cancer2019

TSC2 genetic variant and prognosis in non-small cell lung cancer after curative surgery.

Yong Hoon Lee, Sook Kyung Do, Shin Yup Lee, Hyo-Gyoung Kang, Jin Eun Choi, Mi Jeong Hong, Jang Hyuck Lee, Eung Bae Lee, Ji Yun Jeong, Kyung Min Shin and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thoracic cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Single Nucleotide Polymorphism in the 3' Untranslated Region ofTherapeutics and clinical risk management · 2022
    Article
  4. Pharmacogenomics and personalized medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 3 countries.

Yong Hoon LeeDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Sook Kyung DoDepartment of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Shin Yup LeeDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Hyo-Gyoung KangDepartment of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Jin Eun ChoiDepartment of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Mi Jeong HongDepartment of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Jang Hyuck LeeDepartment of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Eung Bae LeeLung Cancer Center, Kyungpook National University Chilgok Hospital, Daegu, South Korea.
Ji Yun JeongDepartment of Pathology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Kyung Min ShinDepartment of Radiology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Won Kee LeeMedical Research Collaboration Center in Kyungpook National University Hospital and School of Medicine, Kyungpook National University, Daegu, South Korea.
Yangki SeokLung Cancer Center, Kyungpook National University Chilgok Hospital, Daegu, South Korea.
Sukki ChoDepartment of Thoracic and Cardiovascular Surgery, Seoul National University School of Medicine, Seoul, South Korea.
Seung Soo YooDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Jaehee LeeDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Seung Ick ChaDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Chang Ho KimDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Sanghoon JheonDepartment of Thoracic and Cardiovascular Surgery, Seoul National University School of Medicine, Seoul, South Korea.
Jae Yong ParkDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.ORCID 0000-0001-7993-4495
Kyungpook National University · KRKyungpook National University Hospital · KRSeoul National University · KRSoonchunhyang University Hospital Seoul · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was conducted to investigate the associations between polymorphisms of genes involved in the LKB1 pathway and the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Twenty-three single nucleotide polymorphisms (SNPs) in the LKB1 pathway were investigated in 782 patients with NSCLC who underwent curative surgery. The association of SNPs with overall survival (OS) and disease-free survival (DFS) were analyzed. Among the 23 SNPs investigated, TSC2 rs30259G > A was associated with significantly worse OS and DFS (adjusted hazard ratio for OS 1.88, 95% confidence interval 1.21-2.91, P = 0.005; adjusted hazard ratio for DFS 1.65, 95% confidence interval 1.15-2.38, P = 0.01, under codominant models, respectively). Subgroup analysis showed that SNPs were significantly associated with survival outcomes in squamous cell carcinoma, ever-smokers, and stage I, but not in adenocarcinoma, never-smokers, and stage II-IIIA. The results suggest that TSC2 rs30259G > A may be useful to predict prognosis in patients with NSCLC, especially squamous cell carcinoma, after curative surgery.

Indexed as

Polymorphism, Single NucleotideAdenocarcinomaAgedCarcinoma, Large CellCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellCase-Control StudiesFemaleFollow-Up StudiesHumansLung NeoplasmsMalePrognosisRetrospective StudiesSurvival RateTuberous Sclerosis Complex 2 ProteinTSC2 protein, humanTuberous Sclerosis Complex 2 ProteinLung cancerpolymorphismprognosisTSC2

Identifiers

PMID30585697
PMCPMC6360237
OpenAlexW2905790652

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.