Evidence map›Paper›PMID 30585688›Full record

ReviewCellular microbiology2019

Targeting host lipid flows: Exploring new antiviral and antibiotic strategies.

Alberto Fernández-Oliva, Paula Ortega-González, Cristina Risco

Abstract readReview
In one paragraph

Review in Cellular microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Giant viruses encode vitamin K-based redox modules for lipid modification.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Multifaceted role of natural sources for COVID-19 pandemic as marine drugs.Environmental science and pollution research international · 2022
    Review
  8. Plasmalogen Loss in Sepsis and SARS-CoV-2 Infection.Frontiers in cell and developmental biology · 2022
    Article
  9. Review
  10. Review
  11. Article
  12. The role of lipids in the pathophysiology of coronavirus infections.Osong public health and research perspectives · 2021
    Article
  13. Lipid-based therapies against SARS-CoV-2 infection.Reviews in medical virology · 2021
    Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alberto Fernández-OlivaCell Structure Lab, National Centre for Biotechnology, CNB-CSIC, Madrid, Spain.ORCID 0000-0002-2079-2362
Paula Ortega-GonzálezCell Structure Lab, National Centre for Biotechnology, CNB-CSIC, Madrid, Spain.ORCID 0000-0003-2882-3271
Cristina RiscoCell Structure Lab, National Centre for Biotechnology, CNB-CSIC, Madrid, Spain.ORCID 0000-0001-7501-5934

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteria and viruses pose serious challenges for humans because they evolve continuously. Despite ongoing efforts, antiviral drugs to treat many of the most troubling viruses have not been approved yet. The recent launch of new antimicrobials is generating hope as more and more pathogens around the world become resistant to available drugs. But extra effort is still needed. One of the current strategies for antiviral and antibiotic drug development is the search for host cellular pathways used by many different pathogens. For example, many viruses and bacteria alter lipid synthesis and transport to build their own organelles inside infected cells. The characterization of these interactions will be fundamental to identify new targets for antiviral and antibiotic drug development. This review discusses how viruses and bacteria subvert cell machineries for lipid synthesis and transport and summarises the most promising compounds that interfere with these pathways.

Indexed as

AnimalsAnti-Bacterial AgentsAntiviral AgentsBacteriaDrug DiscoveryHost-Pathogen InteractionsHumansLipid MetabolismVirusesAnti-Bacterial AgentsAntiviral Agents

Identifiers

PMID30585688
PMCPMC7162424

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.