ArticleHuman brain mapping2019
White matter during concussion recovery: Comparing diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI).
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diffusion-Weighted Imaging in Mild Traumatic Brain Injury: A Systematic Review of the Literature.Neuropsychology review · 2023Pooled it
- The second decade of DTI in TBI part 1: a systematic review of mild TBI.Frontiers in neurologyPooled it
- Multimodal diffusion MRI biomarkers of white matter alterations and clinical impairment in mTBI.Frontiers in neuroscience · 2026Article
- Detecting glioblastoma infiltration beyond conventional imaging tumour margins using MTE-NODDI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Neurite orientation dispersion and density imaging reveals abnormal white matter and glymphatic function in active young boxers.European journal of sport science · 2024Article
- White Matter Alterations in Military Service Members With Remote Mild Traumatic Brain Injury.JAMA network open · 2024Article
- The Role of Puberty and Sex on Brain Structure in Adolescents With Anxiety Following Concussion.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Assessment of white matter microstructure integrity in subacute postconcussive vestibular dysfunction using NODDI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Effects of post-acute COVID-19 syndrome on cerebral white matter and emotional health among non-hospitalized individuals.Frontiers in neurology · 2024Article
- Headpulse Biometric Measures Following Concussion in Young Adult Athletes.JAMA network open · 2023Article
- Effects of acute alcohol exposure and chronic alcohol use on neurite orientation dispersion and density imaging (NODDI) parameters.Psychopharmacology · 2023Article
- Concussions in young adult athletes: No effect on cerebral white matter.Frontiers in human neuroscience · 2023Article
- C-NODDI: a constrained NODDI model for axonal density and orientation determinations in cerebral white matter.Frontiers in neurology · 2023Article
- Editorial: Manifestations of mild-to-moderate traumatic brain injury.Frontiers in neuroscience · 2023Article
- The relationship between cognition and white matter tract damage after mild traumatic brain injury in a premorbidly healthy, hospitalised adult cohort during the post-acute period.Frontiers in neurology · 2023Article
- Multicompartmental models and diffusion abnormalities in paediatric mild traumatic brain injury.Brain : a journal of neurology · 2022Article
- Post-Concussion Syndrome and Chronic Traumatic Encephalopathy: Narrative Review on the Neuropathology, Neuroimaging and Fluid Biomarkers.Diagnostics (Basel, Switzerland) · 2022Review
- Associations between alcohol consumption and gray and white matter volumes in the UK Biobank.Nature communications · 2022Article
- Traumatic Brain Injury and Risk of Neurodegenerative Disorder.Biological psychiatry · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Concussion pathophysiology in humans remains incompletely understood. Diffusion tensor imaging (DTI) has identified microstructural abnormalities in otherwise normal appearing brain tissue, using measures of fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD). The results of prior DTI studies suggest that acute alterations in microstructure persist beyond medical clearance to return to play (RTP), but these measures lack specificity. To better understand the observed effects, this study combined DTI with neurite orientation dispersion and density imaging (NODDI), which employs a more sophisticated description of water diffusion in the brain. A total of 66 athletes were recruited, including 33 concussed athletes, scanned within 7 days after concussion and at RTP, along with 33 matched controls. Both univariate and multivariate methods identified DTI and NODDI parameters showing effects of concussion on white matter. Spatially extensive decreases in FA and increases in AD and RD were associated with reduced intra-neurite water volume, at both the symptomatic phase of injury and RTP, indicating that effects persist beyond medical clearance. Subsequent analyses also demonstrated that concussed athletes with higher symptom burden and a longer recovery time had greater reductions in FA and increased AD, RD, along with increased neurite dispersion. This study provides the first longitudinal evaluation of concussion from acute injury to RTP using combined DTI and NODDI, significantly enhancing our understanding of the effects of concussion on white matter microstructure.
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