ArticleDevelopment and psychopathology2019
Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors.
Article in Development and psychopathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The Impact of Adverse Childhood Experiences on Cognitive Control Across the Lifespan: A Systematic Review and Meta-analysis of Prospective Studies.Trauma, violence & abuse · 2025Pooled it
- Early deprivation alters structural brain development from middle childhood to adolescence.Science advances · 2022Trial
- Adverse Childhood Experiences and Substance Use: The Mediating Role of Executive Function Deficits.Journal of adolescence · 2026Article
- Inhibitory control-related neural pathways of early adversity to internalizing problems in preadolescence.Journal of affective disorders · 2026Article
- Associations Among Cyberbullying Victimization, Inhibitory Control, Neural Activation of Error Processing, and Mental Health Problems in Adolescents: Neuroimaging, Retrospective Longitudinal Cohort Study Using the Adolescent Brain Cognitive Development Data.Journal of medical Internet research · 2026Article
- Violence Risk Assessment in Individuals With Substance Use Disorders.Actas espanolas de psiquiatria · 2025Article
- The Youth Risk Index: psychometrics, predicting the initiation of early adolescent substance use, and the breadth of liability detected.Frontiers in child and adolescent psychiatry · 2025Article
- Intergenerational Continuity of Childhood Adversity and Its Underlying Mechanisms Among Teen Mothers and Their Offspring.Child maltreatment · 2024Article
- Internalizing Pathways to Adolescent Substance Use from Adverse Childhood Experiences.International journal of environmental research and public health · 2024Article
- Childhood adversity is associated with reduced BOLD response in inhibitory control regions amongst preadolescents from the ABCD study.Developmental cognitive neuroscience · 2024Article
- Cognitive stimulation as a mechanism linking socioeconomic status and neural function supporting working memory: a longitudinal fMRI study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Associations Between Early Life Adversity and Youth Psychobiological Outcomes: Dimensional and Person-Centered Approaches.Research on child and adolescent psychopathology · 2023Article
- A Developmental Psychopathology Perspective on Adverse Childhood Experiences (ACEs): Introduction to the Special Issue.Research on child and adolescent psychopathology · 2023Review
- The Influences of Children's and Maternal Childhood Adversity on Externalizing Problems in Early Adolescence.The Journal of early adolescence · 2023Article
- Adverse childhood experiences, sleep problems, low self-control, and adolescent delinquency: A longitudinal serial mediation analysis.Development and psychopathology · 2023Article
- Childhood trauma predicts blunted error monitoring in adulthood: An event-related potential study.Cognitive, affective & behavioral neuroscience · 2023Article
- Childhood Trauma and Malevolent Creativity in Chinese College Students: Moderated Mediation by Psychological Resilience and Aggression.Journal of Intelligence · 2022Article
- Associations between alexithymia, parental rearing styles, and frequency of drug use in male methamphetamine dependence patients.BMC psychiatry · 2022Article
- Association of Adverse Family Experiences with School Engagement and Performance in US Adolescents: Do Behavioral Health Conditions Mediate the Relationship?The Psychiatric quarterly · 2021Article
- A Narrative Review of Methodological Considerations in Magnetic Resonance Imaging of Offspring Brain Development and the Influence of Parenting.Frontiers in human neuroscience · 2021Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Childhood adversity can negatively impact development across various domains, including physical and mental health. Adverse childhood experiences have been linked to aggression and substance use; however, developmental pathways to explain these associations are not well characterized. Understanding early precursors to later problem behavior and substance use can inform preventive interventions. The aim of the current study was to examine neurobiological pathways through which childhood adversity may lead to early adolescent problem behavior and substance use in late adolescence by testing two prospective models. Our first model found that early adolescent externalizing behavior mediates the association between childhood adversity and alcohol, cigarette, and marijuana use in late adolescence. Our second model found that activation in the anterior cingulate cortex (ACC) during an inhibitory control task mediates the association between childhood adversity and early adolescent externalizing behavior, with lower ACC activation associated with higher levels of adversity and more externalizing behavior. Together these findings indicate that the path to substance use in late adolescence from childhood adversity may operate through lower functioning in the ACC related to inhibitory control and externalizing behavior. Early life stressors should be considered an integral component in the etiology and prevention of early and problematic substance use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.