Evidence map›Paper›PMID 30585335›Full record

Trial reportThe Laryngoscope2019

The Effect of Octanoic Acid on Essential Voice Tremor: A Double-Blind, Placebo-Controlled Study.

Soren Y Lowell, Richard T Kelley, Marika Monahan, Carly Jo Hosbach-Cannon, Raymond H Colton, Dragos Mihaila

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Laryngoscope, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Isolated Voice Tremor: A Clinical Variant of Essential Tremor or a Distinct Clinical Phenotype?Tremor and other hyperkinetic movements (New York, N.Y.) · 2020
    Review
  9. Review
  10. Hyperkinetic Movement Disorders in Children: A Brief Review.Iranian journal of child neurology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Soren Y LowellDepartment of Communication Sciences and Disorders, Syracuse University, Syracuse, New York.ORCID 0000-0001-5168-8122
Richard T KelleyDepartment of Otolaryngology and Communication Sciences, State University of New York Upstate Medical University, Syracuse, New York, U.S.A.
Marika MonahanDepartment of Communication Sciences and Disorders, Syracuse University, Syracuse, New York.
Carly Jo Hosbach-CannonDepartment of Communication Sciences and Disorders, Syracuse University, Syracuse, New York.
Raymond H ColtonDepartment of Communication Sciences and Disorders, Syracuse University, Syracuse, New York.
Dragos MihailaDepartment of Neurology, State University of New York Upstate Medical University, Syracuse, New York, U.S.A.
Syracuse University · USSUNY Upstate Medical University · US

Funding

Effects of octanoic acid for treatment of essential voice tremorR03DC012429 · NIDCD · SYRACUSE UNIVERSITY · PI LOWELL, SOREN YVETTE · 2013 to 2015
$444k
National Institute on Deafness and Other Communication Disorders R03 DC012429NIDCD NIH HHS R03 DC012429
6 · The paper itself

Abstract

objectives/hypothesisThe purpose of this study was to determine the effects of octanoic acid on acoustic, perceptual, and functional aspects of essential voice tremor (EVT). STUDY

designProspective, double-blind, placebo-controlled, crossover study.

methodsSixteen participants with a diagnosis of EVT were randomized to a 3-week dosing condition of octanoic acid or placebo, followed by a 2-week washout period and crossover to the other condition for an additional 3 weeks. Baseline and post-testing sessions were completed before and at the completion of each condition. Primary outcome measures were the magnitude of amplitude and frequency tremor, measured from the acoustic signal. Secondary outcomes were auditory-perceptual ratings of tremor severity and self-ratings of voice handicap.

resultsMagnitude of amplitude and frequency tremor were significantly lower after 3 weeks of octanoic acid dosing as compared to the placebo condition. Auditory-perceptual ratings of tremor severity did not show significant differences between conditions. A trend toward better voice was seen for the sustained vowel ratings, but not the sentence-level ratings. No significant differences between conditions were seen on self-reported voice disability as assessed on the Voice Handicap Index-10.

conclusionsThe results of this controlled investigation support the potential utility of octanoic acid for reducing the magnitude of tremor in people with EVT. Further research is needed to determine whether different dosing or treatment combinations can improve functional communication in EVT. LEVEL OF EVIDENCE: 1 Laryngoscope, 129:1882-1890, 2019.

Indexed as

AgedCaprylatesCross-Over StudiesDouble-Blind MethodEssential TremorFemaleHumansMaleMiddle AgedProspective StudiesSeverity of Illness IndexTreatment OutcomeVoiceVoice DisordersCaprylatesoctanoic acidcross-overessential tremoroctanoic acidplacebo-controlledrandomizedTremorvoice

Identifiers

PMID30585335
PMCPMC6592780
OpenAlexW2905848100

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.