ArticleScience advances2018
Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Clinical outcomes as a function of the number of samples taken during stereotactic needle biopsies: a meta-analysis.Journal of neuro-oncology · 2021Pooled it
- Intraoperative fusion of models and data for robust distance sensing.International journal of computer assisted radiology and surgery · 2026Article
- Biopsy Needle Integrated with Rotational Oblique Spectral Ultrasound (ROSUS) Imaging.Sensors (Basel, Switzerland) · 2026Article
- Intraoperative Fast Adaptive Focus Tracking Robotic OCT Enables Real-Time Tumor Grading and Large-Area Microvascular Imaging in Human Spinal Cord Surgery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Towards Optical Biopsy in Glioma Surgery.International journal of molecular sciences · 2025Review
- Minimally-invasive common-path OCT system for neurosurgery applications.Biomedical optics express · 2025Article
- Intraoperative ex-vivo epifluorescent diagnostics of stereotactic brain biopsies using EndoScell scanner: diagnostic accuracy study.Neurosurgical review · 2025Article
- Optical coherence tomography (OCT) and OCT angiography: Technological development and applications in brain science.Theranostics · 2025Review
- The impact of ondansetron on clinical outcomes in cranial surgery patients: a propensity-matched analysis of retrospective data.Frontiers in aging neuroscience · 2025Article
- Single-fiber probes for combined sensing and imaging in biological tissue: recent developments and prospects.Biomedical optics express · 2024Review
- Advances in Diagnostic Tools and Therapeutic Approaches for Gliomas: A Comprehensive Review.Sensors (Basel, Switzerland) · 2023Review
- Intraoperative Imaging and Optical Visualization Techniques for Brain Tumor Resection: A Narrative Review.Cancers · 2023Review
- Two-photon microendoscope for label-free imaging in stereotactic neurosurgery.Biomedical optics express · 2023Article
- Combined Use of Frameless Neuronavigation and In Situ Optical Guidance in Brain Tumor Needle Biopsies.Brain sciences · 2023Article
- Commonly Overlooked Factors in Biocompatibility Studies of Neural Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Raman Spectroscopy on Brain Disorders: Transition from Fundamental Research to Clinical Applications.Biosensors · 2022Review
- Advances, technological innovations, and future prospects in stereotactic brain biopsies.Neurosurgical review · 2022Review
- Endoscopic imaging of white matter fiber tracts using polarization-sensitive optical coherence tomography.NeuroImage · 2022Article
- An optically-guided cochlear implant sheath for real-time monitoring of electrode insertion into the human cochlea.Scientific reports · 2022Article
- Multimodal imaging needle combining optical coherence tomography and fluorescence for imaging of live breast cancer cells labeled with a fluorescent analog of tamoxifen.Journal of biomedical optics · 2022Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracranial hemorrhage can be a devastating complication associated with needle biopsies of the brain. Hemorrhage can occur to vessels located adjacent to the biopsy needle as tissue is aspirated into the needle and removed. No intraoperative technology exists to reliably identify blood vessels that are at risk of damage. To address this problem, we developed an "imaging needle" that can visualize nearby blood vessels in real time. The imaging needle contains a miniaturized optical coherence tomography probe that allows differentiation of blood flow and tissue. In 11 patients, we were able to intraoperatively detect blood vessels (diameter, >500 μm) with a sensitivity of 91.2% and a specificity of 97.7%. This is the first reported use of an optical coherence tomography needle probe in human brain in vivo. These results suggest that imaging needles may serve as a valuable tool in a range of neurosurgical needle interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.