Evidence map›Paper›PMID 30585267›Full record

Trial reportInternational journal of biological sciences2018

Hepatoprotective effects of limb ischemic post-conditioning in hepatic ischemic rat model and liver cancer patients via PI3K/ERK pathways.

Yanfeng Gao, Shuang Zhou, Fengfei Wang, Yue Zhou, Sen Sheng, Dan Qi, Jason H Huang, Erxi Wu, Yi Lv, Xiongwei Huo

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Yanfeng GaoDepartment of Anesthesiology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Shuang ZhouDepartment of Neurosurgery, Baylor Scott & White Health, Temple, Texas 76502, USA.
Fengfei WangDepartment of Neurosurgery, Baylor Scott & White Health, Temple, Texas 76502, USA.
Yue ZhouDepartment of Statistics, North Dakota State University, Fargo, North Dakota 58105, USA.
Sen ShengDepartment of Neurology, University of Arkansas for Medical Science, Little Rock, Arkansas 72205, USA.
Dan QiDepartment of Neurosurgery, Baylor Scott & White Health, Temple, Texas 76502, USA.
Jason H HuangDepartment of Neurosurgery, Baylor Scott & White Health, Temple, Texas 76502, USA.
Erxi WuDepartment of Neurosurgery, Baylor Scott & White Health, Temple, Texas 76502, USA.
Yi LvDepartment of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Xiongwei HuoDepartment of General Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
First Affiliated Hospital of Xi'an Jiaotong University · CNTexas A&M Health Science Center · USBaylor Scott & White Health · USNorth Dakota State University · USUniversity of Arkansas for Medical Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most effective way of treating liver cancer is surgical resection, which usually requires blocking the hepatic portal circulation, and may result in hepatic ischemia-reperfusion injury (HIRI). It is of paramount importance to control HIRI for liver cancer surgical resection. In this study, a 70% ischemia-reperfusion (I/R) model of rat liver was established, and the protective effect and mechanism of limb ischemic post-conditioning (LIPOC) on HIRI was investigated. We show that LIPOC has a protective effect on hepatic ischemia-reperfusion injury in rats, which reduces the elimination of superoxide dismutase, thereby increasing oxygen free radical scavenging, decreasing lipid peroxidation, inhibiting neutrophil aggregation, as well as reducing TNFα, IL1β, and other inflammatory cytokines. In addition, LIPOC inhibited the apoptosis of hepatocytes induced by I/R injury, and decreased the Bax/Bcl-2 ratio. Furthermore, LIPOC promoted the phosphorylation of Akt and ERK1/2. The use of PI3K inhibitor LY294002 and ERK1/2 blocker PD98059 inhibited the phosphorylation of Akt and ERK1/2 caused by LIPOC and abolished the injury protection of liver I/R. Moreover, through 16 cases of hepatocellular carcinoma resections, we found that short-term LIPOC treatment significantly suppressed the elevated alanine aminotransferase, aspartic transaminase, and total bilirubin in the early post-operation of liver resection, and reduced reperfusion injury to the ischemic liver. In summary, our study demonstrates that LIPOC could be an effective method for HIRI in the clinical implementation of liver resection and uncovers the potential mechanism of LIPOC in the protective effects of HIRI.

Indexed as

AdultAgedAlanine TransaminaseAnimalsApoptosisBlotting, WesternDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFemaleHumansIn Situ Nick-End LabelingIschemiaIschemic PostconditioningLiver NeoplasmsMaleMalondialdehydeAlanine TransaminaseMalondialdehydePeroxidasePhosphatidylinositol 3-KinasesSuperoxide Dismutasehepatectomyhepatic ischemia-reperfusion injurylimb ischemic postconditioning (LIPOC)liver cancerreperfusion injury salvage kinase

Identifiers

PMID30585267
PMCPMC6299361
OpenAlexW2899448151

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.