Evidence map›Paper›PMID 30584981›Full record

ArticleRedox biology2019

Particulate matter induces inflammatory cytokine production via activation of NFκB by TLR5-NOX4-ROS signaling in human skin keratinocyte and mouse skin.

Yea Seong Ryu, Kyoung Ah Kang, Mei Jing Piao, Mee Jung Ahn, Joo Mi Yi, Young-Min Hyun, Seo Hyeong Kim, Min Kyung Ko, Chang Ook Park, Jin Won Hyun

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 1 synthesis or guideline pooled it, 137 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Keratinocytes: pleiotropic orchestrators of cutaneous immunity and Inflammation - Emerging therapeutic paradigms in dermatological pathologies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Air Pollution and Skin Diseases.Annals of dermatology · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yea Seong RyuDepartment of Biochemistry, Jeju National University School of Medicine, Jeju 63243, Republic of Korea.
Kyoung Ah KangDepartment of Biochemistry, Jeju National University School of Medicine, Jeju 63243, Republic of Korea.
Mei Jing PiaoDepartment of Biochemistry, Jeju National University School of Medicine, Jeju 63243, Republic of Korea.
Mee Jung AhnLaboratory of Veterinary Anatomy, College of Veterinary Medicine, Jeju National University, Jeju 63243, Republic of Korea.
Joo Mi YiDepartment of Microbiology and Immunology, Inje University College of Medicine, Busan 47392, Republic of Korea.
Young-Min HyunDepartment of Anatomy, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Seo Hyeong KimDepartment of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Min Kyung KoDepartment of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Chang Ook ParkDepartment of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Jin Won HyunDepartment of Biochemistry, Jeju National University School of Medicine, Jeju 63243, Republic of Korea. Electronic address: jinwonh@jejunu.ac.kr.
Jeju National University · KRYonsei University · KRInje University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Particulate matter (PM) increases levels of pro-inflammatory cytokines, but its effects on the skin remain largely unknown. We investigated the signal transduction pathway and epigenetic regulatory mechanisms underlying cellular inflammation induced by PM with a diameter of ≤ 2.5 (PM

Indexed as

AnimalsCell LineCells, CulturedCytokinesEpigenesis, GeneticHumansInflammation MediatorsKeratinocytesMiceModels, BiologicalNADPH Oxidase 4NF-kappa BOxidative StressParticulate MatterPromoter Regions, GeneticReactive Oxygen SpeciesCytokinesInflammation MediatorsNADPH Oxidase 4NF-kappa BParticulate MatterReactive Oxygen SpeciesToll-Like Receptor 5Epigenetic modificationInterleukin-6Particulate matterReactive oxygen speciesToll like receptor

Identifiers

PMID30584981
PMCPMC6305701
OpenAlexW2904006811

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.