Evidence map›Paper›PMID 30584900›Full record

ArticleBiochimica et biophysica acta. Molecular cell research2019

Novel CaM-binding motif in its NudT9H domain contributes to temperature sensitivity of TRPM2.

Ellen Gattkowski, Anke Johnsen, Andreas Bauche, Franziska Möckl, Frederike Kulow, Maria Garcia Alai, Trevor J Rutherford, Ralf Fliegert, Henning Tidow

Open access · hybridAbstract read
In one paragraph

Article in Biochimica et biophysica acta. Molecular cell research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Dual amplification strategy turns TRPM2 channels into supersensitive central heat detectors.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ellen GattkowskiThe Hamburg Centre for Ultrafast Imaging & Department of Chemistry, Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany; Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.
Anke JohnsenDepartment of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.
Andreas BaucheDepartment of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.
Franziska MöcklDepartment of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.
Frederike KulowDepartment of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.
Maria Garcia AlaiEuropean Molecular Biology Laboratory Hamburg, Notkestrasse 85, D-22607 Hamburg, Germany.
Trevor J RutherfordMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom.
Ralf FliegertDepartment of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany. Electronic address: r.fliegert@uke.de.
Henning TidowThe Hamburg Centre for Ultrafast Imaging & Department of Chemistry, Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany. Electronic address: tidow@chemie.uni-hamburg.de.
University Medical Center Hamburg-Eppendorf · DEUniversität Hamburg · DEEuropean Molecular Biology Laboratory · DEMRC Laboratory of Molecular Biology · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TRPM2 is a non-selective, Ca

Indexed as

Hot TemperatureAmino Acid MotifsHEK293 CellsHumansProtein DomainsProtein StabilityTRPM Cation ChannelsTRPM2 protein, humanTRPM Cation Channels2′-deoxy-ADPRCalcium channelCalmodulin-bindingTemperature sensorTRPM2

Identifiers

PMID30584900
PMCPMC6646794
OpenAlexW2906201775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.