Evidence map›Paper›PMID 30584890›Full record

ReviewArchives of biochemistry and biophysics2019

The missing links within troponin.

Mayra A Marques, Michelle S Parvatiyar, Wei Yang, Guilherme A P de Oliveira, Jose R Pinto

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Archives of biochemistry and biophysics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Nucleus Mechanosensing in Cardiomyocytes.International journal of molecular sciences · 2023
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Current and Future Directions of Myofilament Regulation.Archives of biochemistry and biophysics · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mayra A MarquesPrograma de Biologia Estrutural, Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Centro Nacional de Ressonância Magnética Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Michelle S ParvatiyarDepartment of Nutrition, Food and Exercise Sciences, Florida State University, 107 Chieftan Way, Tallahassee, FL, 32306-1493, USA.
Wei YangDepartment of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Kasha Laboratory Building, 91 Chieftan Way, Tallahassee, FL, 32306-4380, USA.
Guilherme A P de OliveiraPrograma de Biologia Estrutural, Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Centro Nacional de Ressonância Magnética Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, 22908-0733, USA. Electronic address: gaugusto@bioqmed.ufrj.br.
Jose R PintoDepartment of Biomedical Sciences, Florida State University College of Medicine, 1115 West Call Street, Tallahassee, FL, 32306-4300, USA. Electronic address: jose.pinto@med.fsu.edu.

Funding

Modulators of Cardiomyopathic DiseasesR01HL128683 · NHLBI · FLORIDA STATE UNIVERSITY · PI PINTO, JOSE RENATO · 2016 to 2020
$1.8M
Understanding Protein-Ligand RecogntionR01GM111886 · NIGMS · FLORIDA STATE UNIVERSITY · PI YANG, WEI · 2014 to 2018
$1.5M
NHLBI NIH HHS R01 HL128683NIGMS NIH HHS R01 GM111886
6 · The paper itself

Abstract

The cardiac contraction-relaxation cycle is controlled by a sophisticated set of machinery. Of particular interest, is the revelation that allosteric networks transmit effects of binding at one site to influence troponin complex dynamics and structural-mediated signaling in often distal, functional sites in the myofilament. Our recent observations provide compelling evidence that allostery can explain the function of large-scale macromolecular events. Here we elaborate on our recent findings of interdomain communication within troponin C, using cutting-edge structural biology approaches, and highlight the importance of unveiling the unknown, distant communication networks within this system to obtain more comprehensive knowledge of how allostery impacts cardiac physiology and disease.

Indexed as

Allosteric RegulationAmino Acid SequenceAnimalsHumansProtein BindingStructure-Activity RelationshipTroponin CTroponin ITroponin CTroponin IAllosteryDynamicsStructural biologyThin filamentTroponin

Identifiers

PMID30584890
PMCPMC6377831

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.