Evidence map›Paper›PMID 30584782›Full record

Trial reportIntegrative cancer therapies

Influence of a Multimodal and Multimodal-Aerobic Therapy Concept on Health-Related Quality of Life in Breast Cancer Survivors.

Désirée Poier, Arndt Büssing, Daniela Rodrigues Recchia, Yvonne Beerenbrock, Marcus Reif, Andreas Nikolaou, Roland Zerm, Christoph Gutenbrunner, Matthias Kröz

Abstract readMulticenter StudyRandomized Controlled TrialPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Cardiovascular training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2025
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  13. The intersection of heart failure and cancer in women: a review.Frontiers in cardiovascular medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Désirée Poier1 Witten/Herdecke University, Herdecke, Germany.
Arndt Büssing1 Witten/Herdecke University, Herdecke, Germany.
Daniela Rodrigues Recchia1 Witten/Herdecke University, Herdecke, Germany.
Yvonne Beerenbrock1 Witten/Herdecke University, Herdecke, Germany.
Marcus Reif2 Society for Clinical Research, Berlin, Germany.
Andreas Nikolaou3 Hannover Medical School, Hannover, Germany.
Roland Zerm4 Research Institute Havelhoehe, Berlin, Germany.
Christoph Gutenbrunner3 Hannover Medical School, Hannover, Germany.
Matthias Kröz1 Witten/Herdecke University, Herdecke, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextCancer-related fatigue (CRF) is one of the most burdensome symptoms in breast cancer survivors (BCSs), accompanied by reduced health-related quality of life (HRQOL).

objectivesThis study investigated the influence of a multimodal therapy (MT; psychoeducation, eurythmy therapy, painting therapy, and sleep education/restriction), or a combination therapy (CT; MT plus aerobic training [AT]) on HRQOL in BCS with chronic CRF in comparison with AT alone.

methodsOne hundred and twenty-six BCSs with CRF were included in a pragmatic comprehensive cohort study and allocated either per randomization or by preference to MT, CT, or AT. The EORTC QLQ-C30 core questionnaire was used to measure HRQOL. All analyses on HRQOL parameters were done in an explorative intention.

resultsPatients were assigned to MT (n = 44), CT (n = 54), or AT (n = 28). CT was significantly superior to AT after 10 weeks of intervention (T1) in improving physical function. MT was found to have significant superiority over AT at T1 and T2 for physical functioning, emotional functioning, insomnia, and financial problems as well as role functioning, cognitive, social functioning, and fatigue 6 months later (T2).

conclusionA multimodal approach appears to be a suitable concept for BCS with chronic CRF. A confirmatory study with larger samples should demonstrate the superiority of MT and adapted CT in HRQOL compared with the current treatment AT found in these explorative analyses.

Indexed as

Breast NeoplasmsCancer SurvivorsExerciseExercise TherapyFatigueFemaleHealth StatusHumansMiddle AgedProspective StudiesQuality of LifeSleepSleep Initiation and Maintenance DisordersSurveys and Questionnairesaerobic traininganthroposophic medicinebreast cancercancer-related fatiguehealth-related quality of lifemultimodal therapy

Identifiers

PMID30584782
PMCPMC6432685

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.