Evidence map›Paper›PMID 30584686›Full record

ArticleHead & neck2019

Tumor multifocality with vagus nerve involvement as a phenotypic marker of SDHD mutation in patients with head and neck paragangliomas: A

Vincent Amodru, Pauline Romanet, Ugo Scemama, Marion Montava, Nicolas Fakhry, Frédéric Sebag, Frédéric Castinetti, Jean-Pierre Lavieille, Anderson Loundou, Arthur Varoquaux and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Clinical characteristics and prognosis ofJournal of medical genetics · 2026
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Vincent AmodruDepartment of Endocrinology, Conception University Hospital, Aix-Marseille University, Marseille, France.
Pauline RomanetLaboratory of Molecular Biology, Conception Hospital & CNRS, CRN2M UMR 7286, Aix-Marseille University, Marseille, France.
Ugo ScemamaDepartment of Radiology, Conception Hospital, Aix-Marseille University, Marseille, France.
Marion MontavaDepartment of Otorhinolaryngology-Head and Neck Surgery, Conception Hospital, Aix-Marseille University, Marseille, France.
Nicolas FakhryDepartment of Otorhinolaryngology-Head and Neck Surgery, Conception Hospital, Aix-Marseille University, Marseille, France.
Frédéric SebagDepartment of Endocrine Surgery, Conception University Hospital, Aix-Marseille University, Marseille, France.
Frédéric CastinettiDepartment of Endocrinology, Conception University Hospital, Aix-Marseille University, Marseille, France.
Jean-Pierre LavieilleLaboratory of Molecular Biology, Conception Hospital & CNRS, CRN2M UMR 7286, Aix-Marseille University, Marseille, France.
Anderson LoundouDepartment of Public Health, EA3279 Self-perceived Health Assessment Research Unit, La Timone University, Aix-Marseille University, Marseille, France.
Arthur VaroquauxDepartment of Radiology, Conception Hospital, Aix-Marseille University, Marseille, France.
Anne BarlierLaboratory of Molecular Biology, Conception Hospital & CNRS, CRN2M UMR 7286, Aix-Marseille University, Marseille, France.
Karel PacakSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, Maryland.
David TaïebDepartment of Nuclear Medicine, La Timone University Hospital, Aix-Marseille University, Marseille, France.ORCID 0000-0002-0400-7600
Aix-Marseille Université · FRCentre National de la Recherche Scientifique · FRNational Institutes of Health · US

Funding

Diagnosis, Pathophysiology And Molecular Biology of Pheochromocytoma and ParagangliomaZIAHD008735 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PACAK, KAREL · 2009 to 2024
$28.4M
Intramural NIH HHS Z99 HD999999
6 · The paper itself

Abstract

background

methodsA total of 104 patients with HNPGL (65 sporadic/39 SDHx-mutated) were included.

resultsIn comparison to SDHB/SDC/SDHx-negative cases, patients with SDHD were younger at diagnosis and had a higher rate of multifocal, vagal, and carotid paraganglioma. In patients with SDHD, vagal paraganglia represented the primary site of tumor origin. Multicentric involvement of the vagus nerve alone or in association with other locations was found to be a typical feature of SDHD cases compared to other cases (odds ratio = 59.4).

conclusionThe present study shows that tumor multifocality within the vagus nerve is a phenotypic marker of SDHD mutation. This information is essential in the choice of the therapeutic strategy.

Indexed as

MutationPositron Emission Tomography Computed TomographyAge FactorsCranial Nerve NeoplasmsDihydroxyphenylalanineFemaleFluorine RadioisotopesHead and Neck NeoplasmsHeterozygoteHumansMaleMiddle AgedNeoplasms, Multiple PrimaryParaganglioma, Extra-AdrenalPhenotypeRetrospective StudiesDihydroxyphenylalanineFluorine Radioisotopesfluorodopa F 18SDHD protein, humanSuccinate Dehydrogenasediagnostic imaginggeneticsparagangliomasvagus nerve

Identifiers

PMID30584686
PMCPMC7350654
OpenAlexW2905997405

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.