ArticleJournal of magnetic resonance imaging : JMRI2019
Quantitative susceptibility mapping of articular cartilage in patients with osteoarthritis at 3T.
Article in Journal of magnetic resonance imaging : JMRI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Simultaneous 3-D Adiabatic TNMR in biomedicine · 2026Article
- MC BTS: Simultaneously Resolving Magnetization Transfer Effect and Relaxation for Multiple Components.Magnetic resonance in medicine · 2026Article
- Addressing fatty tissue in quantitative susceptibility mapping of human knee cartilage.Magma (New York, N.Y.) · 2025Article
- Simultaneous 3D quantitative magnetization transfer imaging and susceptibility mapping.Magnetic resonance in medicine · 2025Article
- Quantitative susceptibility and T1Osteoarthritis and cartilage open · 2024Article
- Application research of AI-assisted compressed sensing technology in MRI scanning of the knee joint: 3D-MRI perspective.European radiology · 2024Article
- Cartilage morphometry and magnetic susceptibility measurement for knee osteoarthritis with automatic cartilage segmentation.Quantitative imaging in medicine and surgery · 2023Article
- QSM Throughout the Body.Journal of magnetic resonance imaging : JMRI · 2023Review
- Simultaneous Quantitative Susceptibility Mapping of Articular Cartilage and Cortical Bone of Human Knee Joint Using Ultrashort Echo Time Sequences.Frontiers in endocrinology · 2022Article
- Multimodal Magnetic Resonance Imaging to Diagnose Knee Osteoarthritis under Artificial Intelligence.Computational intelligence and neuroscience · 2022Article
- Articular Cartilage Assessment Using Ultrashort Echo Time MRI: A Review.Frontiers in endocrinology · 2022Review
- Asymmetric susceptibility tensor imaging.Magnetic resonance in medicine · 2021Article
- Morphological MRI of knee cartilage: repeatability and reproducibility of damage evaluation and correlation with gross pathology examination.European radiology · 2020Article
- Comparison of Clinical and Imaging Outcomes of Different Doses of Adipose-Derived Stromal Vascular Fraction Cell Treatment for Knee Osteoarthritis.Cell transplantationArticle
- Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundQuantitative susceptibility mapping (QSM) has recently been applied in humans to quantify the magnetic susceptibility of collagen fibrils in the articular cartilage. PURPOSE: To determine the ability of QSM to detect cartilage matrix degeneration between normal and early knee osteoarthritis (OA) patients. STUDY TYPE: Prospective. POPULATION: Twenty-four patients with knee OA and 24 age- and sex-matched healthy controls. FIELD STRENGTH/SEQUENCE: 3D gradient echo, T ASSESSMENT: Scan-rescan reproducibility of the susceptibility values in the cartilage was assessed in control subjects. Cartilage thickness, volume, mean, and standard deviation (SD) of susceptibility values of the cartilage compartments were compared between normal and OA patients. The relationship between magnetic susceptibility values and cartilage lesion grading based on MR images was studied. STATISTICAL TESTS: The Wilcoxon Rank-Sum test was used to compare cartilage thickness, volume, mean, and SD of susceptibility values between control subjects and OA patients. A Spearman rank correlation was performed to study the relationship between the mean and SD of susceptibility values and the cartilage thinning grades.
resultsThe SD of magnetic susceptibility values in the knee cartilage was significantly lower in OA patients compared with healthy controls, and it decreased with more severe MR grades of cartilage thinning degeneration. Significant correlations between the SD of susceptibility values and cartilage thinning grades were observed with R DATA
conclusionThe variations of susceptibility values in the knee cartilage decrease with the degree of cartilage degeneration. QSM may be a sensitive indicator for alteration of the collagen network and shows potential to detect cartilage degeneration at early stage. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018.
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