Evidence map›Paper›PMID 30584595›Full record

ArticleNeurology. Genetics2018

Amyloid- and tau-PET imaging in a familial prion kindred.

David T Jones, Ryan A Townley, Jonathan Graff-Radford, Hugo Botha, David S Knopman, Ronald C Petersen, Clifford R Jack, Val J Lowe, Bradley F Boeve

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

David T JonesDepartment of Neurology (D.T.J., R.A.T., J.G.-R., H.B., D.S.K., R.C.P., B.F.B.) and Department of Radiology (D.T.J., C.R.J., V.J.L.), Mayo Clinic, Rochester, MN.
Ryan A TownleyDepartment of Neurology (D.T.J., R.A.T., J.G.-R., H.B., D.S.K., R.C.P., B.F.B.) and Department of Radiology (D.T.J., C.R.J., V.J.L.), Mayo Clinic, Rochester, MN.
Jonathan Graff-RadfordDepartment of Neurology (D.T.J., R.A.T., J.G.-R., H.B., D.S.K., R.C.P., B.F.B.) and Department of Radiology (D.T.J., C.R.J., V.J.L.), Mayo Clinic, Rochester, MN.
Hugo BothaDepartment of Neurology (D.T.J., R.A.T., J.G.-R., H.B., D.S.K., R.C.P., B.F.B.) and Department of Radiology (D.T.J., C.R.J., V.J.L.), Mayo Clinic, Rochester, MN.
David S KnopmanDepartment of Neurology (D.T.J., R.A.T., J.G.-R., H.B., D.S.K., R.C.P., B.F.B.) and Department of Radiology (D.T.J., C.R.J., V.J.L.), Mayo Clinic, Rochester, MN.
Ronald C PetersenDepartment of Neurology (D.T.J., R.A.T., J.G.-R., H.B., D.S.K., R.C.P., B.F.B.) and Department of Radiology (D.T.J., C.R.J., V.J.L.), Mayo Clinic, Rochester, MN.
Clifford R JackDepartment of Neurology (D.T.J., R.A.T., J.G.-R., H.B., D.S.K., R.C.P., B.F.B.) and Department of Radiology (D.T.J., C.R.J., V.J.L.), Mayo Clinic, Rochester, MN.
Val J LoweDepartment of Neurology (D.T.J., R.A.T., J.G.-R., H.B., D.S.K., R.C.P., B.F.B.) and Department of Radiology (D.T.J., C.R.J., V.J.L.), Mayo Clinic, Rochester, MN.
Bradley F BoeveDepartment of Neurology (D.T.J., R.A.T., J.G.-R., H.B., D.S.K., R.C.P., B.F.B.) and Department of Radiology (D.T.J., C.R.J., V.J.L.), Mayo Clinic, Rochester, MN.
Mayo Clinic in Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study the in vivo binding properties of

methodsA case series of 4 symptomatic family members with the 12-octapeptide repeat insertion in the

resultsThere was significant neocortical uptake of the tau-PET tracer in all 4 familial prion cases. However, PiB-PET images did not demonstrate abnormally elevated signal in neocortical or cerebellar regions for any of the patients.

conclusionsIn vivo detection of molecular hallmarks of neurodegenerative diseases will be a prerequisite to well-conducted therapeutic trials. Understanding the in vivo behavior of these PET biomarkers in the setting of various neurodegenerative processes is imperative to their proper use in such trials and for research studies focused on the basic neurobiology of neurodegeneration. This study supports the high specificity of neocortical

Identifiers

PMID30584595
PMCPMC6283453
OpenAlexW2902175502

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.