ArticleJournal of medical biochemistry2018
Uncertainty of Measurement in Laboratory Medicine.
Article in Journal of medical biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Are accreditation standards fit for measurement uncertainty in clinical laboratories? An analysis of Saudi Arabia's accreditation.Frontiers in medicine · 2026Article
- Metrological Evaluation of Metopimazine HPLC Assay: ISO-GUM and Monte Carlo Simulation Approaches.Pharmaceutics · 2025Article
- Review
- A Comparative Study for Measuring Serum Ferritin Levels with Three Different Laboratory Methods: Enzyme-Linked Immunosorbent Assay versus Cobas e411 and Cobas Integra 400 Methods.Diagnostics (Basel, Switzerland) · 2022Article
- Verification of quantitative analytical methods in medical laboratories.Journal of medical biochemistry · 2021Article
- Estimation of the measurement uncertainty and practical suggestion for the description of the metrological traceability in clinical laboratories.Biochemia medica · 2021Review
- Newborns bilirubin concentration determined by different methods in relation to hematocrit and albumin level.Journal of medical biochemistry · 2020Article
- Changes in the proteomic profile of blood serum in coronary atherosclerosis.Journal of medical biochemistry · 2020Article
- Leukocytosis interference in clinical chemistry: Shall we still interpret test results without hematological data?Journal of medical biochemistry · 2020Article
- Measuring plasma ferritin levels with two different methods: A comparison of Roche Cobas e601 versus Roche Cobas c501 (integrated modular system Roche Cobas 6000).Journal of medical biochemistry · 2020Article
- Glucose meters: What's the laboratory reference glucose?Journal of medical biochemistry · 2020Article
- Peripheral neural response and sex hormones in type 1 Gaucher disease.Journal of medical biochemistry · 2020Article
- NLRP3 and CARD8 polymorphisms influence risk for asbestos-related diseases.Journal of medical biochemistry · 2020Article
- Interpol review of toxicology 2016-2019.Forensic science international. Synergy · 2020Review
- CD4/CD8 Ratio as a Predictor for the Occurrence of Metabolic Syndrome in HIV / AIDS Patients During 6 Months of cART Therapy.Journal of medical biochemistry · 2019Article
- The Importance of RET-He in the Diagnosis of Iron Deficiency and Iron Deficiency Anemia and the Evaluation of Response to Oral Iron Therapy.Journal of medical biochemistry · 2019Article
- Predictive Values of Serum Uric Acid and Alanine-aminotransferase for Fatty Liver Index in Montenegrin Population.Journal of medical biochemistry · 2019Article
- Determining the Need for Repeat Testing of Blood Ethanol Concentration: Evaluation of the Synchron Blood Ethyl Alcohol Assay Kit.Journal of medical biochemistry · 2019Article
- Nitric Oxide Products are not Associated with Metabolic Syndrome.Journal of medical biochemistry · 2019Article
- Exploring Sirolimus Pharmacokinetic Variability Using Data Available from the Routine Clinical Care of Renal Transplant Patients - Population Pharmacokinetic Approach.Journal of medical biochemistry · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An adequate assessment of the measurement uncertainty in a laboratory medicine is one of the most important factors for a reliable interpretation of the results. A large number of standards and guidelines indicate the need for a proper assessment of the uncertainty of measurement results in routine laboratory practice. The available documents generally recommend participation in the proficiency schemes/ external quality control, as well as the internal quality control, in order to primarily verify the quality performance of the method. Although all documents meet the requirements of the International Standard, ISO 15189, the standard itself does not clearly define the method by which the measurement results need to be assessed and there is no harmonization in practice regarding to this. Also, the uncertainty of measurement results is the data relating to the measured result itself, but all factors that influence the interpretation of the measured value, which is ultimately used for diagnosis and monitoring of the patient's treatment, should be taken into account. So in laboratory medicine, an appropriate assessment of the uncertainty of the measurement results should have the ultimate goal of reducing diagnostic uncertainty. However, good professional laboratory practice and understanding analytical aspects of the test for each individual laboratory is necessary to adequately define the uncertainty of measurement results for specific laboratory tests, which helps to implement good clinical practice. Also, setting diagnoses in medicine is a decision with a certain degree of uncertainty, rather than statistically and mathematically calculated conclusion.
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