Evidence map›Paper›PMID 30584332›Full record

ArticleOncoTargets and therapy2018

Overexpression of NELFCD promotes colorectal cancer cells proliferation, migration, and invasion.

Shenglei Song, Daojiang Li, Chunxing Yang, Peicheng Yan, Yang Bai, Yi Zhang, Gui Hu, Changwei Lin, Xiaorong Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Identification ofFrontiers in cell and developmental biology · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Shenglei SongDepartment of Gastrointestinal Surgery, The Third Xiang Ya Hospital of Central South University, Changsha, Hunan 410013, China, xiaorongli@csu.edu.cn; linchangwei1987@csu.edu.cn.
Daojiang LiDepartment of Gastrointestinal Surgery, The Third Xiang Ya Hospital of Central South University, Changsha, Hunan 410013, China, xiaorongli@csu.edu.cn; linchangwei1987@csu.edu.cn.
Chunxing YangDepartment of Gastrointestinal Surgery, The Third Xiang Ya Hospital of Central South University, Changsha, Hunan 410013, China, xiaorongli@csu.edu.cn; linchangwei1987@csu.edu.cn.
Peicheng YanDepartment of Gastrointestinal Surgery, The Third Xiang Ya Hospital of Central South University, Changsha, Hunan 410013, China, xiaorongli@csu.edu.cn; linchangwei1987@csu.edu.cn.
Yang BaiDepartment of Gastrointestinal Surgery, The Third Xiang Ya Hospital of Central South University, Changsha, Hunan 410013, China, xiaorongli@csu.edu.cn; linchangwei1987@csu.edu.cn.
Yi ZhangDepartment of Gastrointestinal Surgery, The Third Xiang Ya Hospital of Central South University, Changsha, Hunan 410013, China, xiaorongli@csu.edu.cn; linchangwei1987@csu.edu.cn.
Gui HuDepartment of Gastrointestinal Surgery, The Third Xiang Ya Hospital of Central South University, Changsha, Hunan 410013, China, xiaorongli@csu.edu.cn; linchangwei1987@csu.edu.cn.
Changwei LinDepartment of Gastrointestinal Surgery, The Third Xiang Ya Hospital of Central South University, Changsha, Hunan 410013, China, xiaorongli@csu.edu.cn; linchangwei1987@csu.edu.cn.
Xiaorong LiDepartment of Gastrointestinal Surgery, The Third Xiang Ya Hospital of Central South University, Changsha, Hunan 410013, China, xiaorongli@csu.edu.cn; linchangwei1987@csu.edu.cn.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNegative elongation factor complex member C/D (NELFCD), mapped to chromosome 20q13.32, has been found to be significantly overexpressed in colorectal cancer (CRC) by our previous research. However, whether its overexpression contributes to CRC development is unknown. We aimed to explore the biological and clinical roles of NELFCD in CRC. MATERIALS AND

methodsThe expression of NELFCD was detected by qRT-PCR and Western blot. The biological function of NELFCD on CRC cell proliferation, migration, invasion, and apoptosis was detected by cell counting kit-8, plate colony formation assay, transwell migration and invasion assays, and flow cytometry in vitro and by murine xenograft tumor growth in vivo. Moreover, we evaluated the correction between its expression level and clinicopathologic parameters.

resultsWe found NELFCD was overexpressed in 50 pairs of CRC tissues in comparison to the adjacent nontumor tissues (

conclusionNELFCD is overexpressed and plays an oncogenic role in CRC. Targeting NELFCD may provide a potential therapeutic option for NELFCD-amplified tumors.

Indexed as

colorectal carcinomaCRCNELFCDoncogene

Identifiers

PMID30584332
PMCPMC6287418
OpenAlexW2903281576

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.