Evidence map›Paper›PMID 30584162›Full record

ReviewJournal of Parkinson's disease2018

Therapies to Slow, Stop, or Reverse Parkinson's Disease.

Tom Foltynie, J William Langston

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of Parkinson's disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. The Effects of a Dance and Music-Based Intervention on Parkinson's Patients' Well-Being: An Interview Study.International journal of environmental research and public health · 2022
    Article
  4. T cells, α-synuclein and Parkinson disease.Handbook of clinical neurology · 2022
    Review
  5. Review
  6. Review
  7. Parkinson's Disease: We Care!Journal of Parkinson's disease · 2020
    Article
  8. What People with Parkinson's Disease Want.Journal of Parkinson's disease · 2020
    Review
  9. Article
  10. Probiotics for Parkinson's Disease.International journal of molecular sciences · 2019
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Tom FoltynieDepartment of Clinical and Movement Neurosciences, UCL Institute of Neurology & The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
J William LangstonDepartment of Pathology, Associate Director, Stanford Udall Center, Stanford, CA, USA.
National Hospital for Neurology and Neurosurgery · GBStanford Medicine · US

Funding

Udall Center Director's meeting poster awardP50NS062684 · NINDS · UNIVERSITY OF WASHINGTON · PI MONTINE, THOMAS J · 2009 to 2020
$18.3M
NINDS NIH HHS P50 NS062684
6 · The paper itself

Abstract

Our understanding of PD pathophysiology is vastly improved compared to the situation 20 years ago. We have identified the major genetic risks for PD, we now have far more representative animal models of the disease, and we can be inspired by the early successes of others using Antisense Oligonucleotide and vaccination approaches in other neurodegenerative diseases. We also have a broad range of repurposed drugs showing the first signals of potential efficacy in the translational pipeline which are being driven forward through the various clinical trial stages. We believe we can be optimistic that the next 20 years will be a time for major breakthroughs towards the discovery of therapies that may slow, stop, or reverse PD.

Indexed as

NeuroprotectionDisease ProgressionHumansParkinson Diseasedisease-modifyingneuroprotectionParkinson’s disease

Identifiers

PMID30584162
PMCPMC6311371
OpenAlexW2904644412

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.