Evidence map›Paper›PMID 30584154›Full record

ReviewJournal of Parkinson's disease2018

Towards Personalized Rehabilitation for Gait Impairments in Parkinson's Disease.

Jorik Nonnekes, Alice Nieuwboer

3 registry-linked trialsAbstract readReview
In one paragraph

Review in Journal of Parkinson's disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05478187 nacompletednot on this mapstarted 2019, after this paper: background citation

A Wearable Visual Cueing System for Gait Rehabilitation in Parkinson's Disease: a Randomized Controlled Trial.

TypeinterventionalSponsorHabilita, Ospedale di SarnicoRan2019 to 2021Enrolled52ConditionsParkinson Disease, Movement Disorders, Gait Disorders, NeurologicArmsQWalk Study Group, Traditional visual cues - Control group
NCT05733819 phase1completednot on this mapstarted 2023, after this paper: background citation

Responders to Metronome-based Rhythmic Auditory Cueing in Parkinson Disease

TypeinterventionalSponsorBoston University Charles River CampusRan2023 to 2023Enrolled31ConditionsParkinson DiseaseArmsSubject-specific optimized RAS, Active Walking
NCT06789133 nacompletednot on this mapstarted 2024, after this paper: background citation

Effects of Gait Training With and Without Proprioceptive Neuromuscular Facilitation on Balance, Gait and Activities of Daily Living in Parkinson's Patients

TypeinterventionalSponsorRiphah International UniversityRan2024 to 2024Enrolled36ConditionsParkinson Disease (PD), Proprioceptive Neuromuscular FacilitationArmsPNF exercises and Body weight supported treadmill gait training, Body weight supported treadmill gait training and Routine physical therapy
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Interventions for preventing falls in Parkinson's disease.The Cochrane database of systematic reviews · 2022
    Pooled it
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  7. Walking as a Window to the Brain: Redefining Gait in Neurology.Medical sciences (Basel, Switzerland) · 2026
    Review
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  20. Analyzing population-level trials as N-of-1 trials: An application to gait.Contemporary clinical trials communications · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jorik NonnekesRadboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Department of Rehabilitation, Nijmegen, The Netherlands.
Alice NieuwboerDepartment of Rehabilitation Sciences, Katholieke Universiteit Leuven, Tervuursevest, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-pharmacological interventions are essential in the management of gait impairments in Parkinson's disease. The evidence for these interventions is growing rapidly. However, studies evaluating these interventions do generally evaluate a one-size-fits-all concept, and do usually not distinguish between subgroups, treatment dose and delivery mode. For two main reasons, this approach will not reach the full potential of gait rehabilitation. First, non-pharmacological interventions (e.g., external cueing) can improve gait in certain patients, but have no effect or sometimes even exacerbate gait deficits in others. Second, the success and benefit of gait rehabilitation relies on therapy adherence and training intensity achieved, and multi-target therapy not tailored to the individual runs the risk of hitting nothing. Hence, to apply non-pharmacological interventions in an individualized and evidence-based manner, clinicians and therapists need to know which patient characteristics predict the efficacy of various training modes and what type of training delivery works best. Current evidence is not sufficient to develop such personalized rehabilitation programs. In this viewpoint, however, we describe how tailored use of gait rehabilitation can be reached within a 20-year time frame.

Indexed as

Activities of Daily LivingGaitPhysical Therapy ModalitiesPrecision MedicineExercise TherapyGait Disorders, NeurologicHumansParkinson DiseaseQuality of Lifebalancefallsfreezing of gaitGaitParkinson’s diseasepersonalized medicinephysiotherapyrehabilitation

Identifiers

PMID30584154
PMCPMC6311370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.