ArticleProceedings of the National Academy of Sciences of the United States of America2019
LAMP-2B regulates human cardiomyocyte function by mediating autophagosome-lysosome fusion.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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80citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
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Who cites it
80 citing papers in PubMed, 124 citations in OpenAlex.
- Enhanced glucose uptake in cardiac and skeletal muscles in Danon disease results from the impaired chaperone-mediated autophagy.Cell & bioscience · 2026Article
- Targeting VAMPs in Aging-Related Diseases: From Mechanisms to Pharmacotherapy.Pharmaceutical research · 2026Review
- The ATG14: multi-layer autophagy control and an emerging therapeutic target in cancer.Apoptosis : an international journal on programmed cell death · 2026Review
- Danon disease: Two case reports and literature review.Medicine · 2026Review
- Silent controllers: non-coding RNAs drive autophagic response in myocardial ischemia reperfusion injury.Frontiers in cardiovascular medicine · 2026Review
- Danon Disease: Understanding the Role of LAMP2 Variants in Cardiomyopathy and Multisystemic Involvement.Arquivos brasileiros de cardiologia · 2026Review
- From chromatin to proteostasis: multilevel gene regulation in Mendelian diseases.Frontiers in epigenetics and epigenomics · 2026Review
- The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells.FEBS open bio · 2026Article
- Generation of human induced pluripotent stem cell lines from a fetus with congenital long QT syndrome and her healthy parents.Stem cell research · 2025Article
- Lysosome heterogeneity and diversity mapped through its distinct cellular functions.Cellular and molecular life sciences : CMLS · 2025Review
- Roles of Autophagy and Oxidative Stress in Cardiovascular Disease.Antioxidants (Basel, Switzerland) · 2025Review
- Bi-allelic deleterious variants in SNAPIN, which encodes a retrograde dynein adaptor, cause a prenatal-onset neurodevelopmental disorder.American journal of human genetics · 2025Article
- PF-04691502, a PI3K/mTOR Dual Inhibitor, Ameliorates AD-like Pathology in a Mouse Model of AD.Cells · 2025Article
- The MEK inhibitor trametinib incurs mitochondrial injury and induces innate immune responses in the mouse heart.bioRxiv : the preprint server for biology · 2025Article
- Overlapping functions betweenAutophagy · 2025Article
- LAMP2-FLOT2 interaction enhances autophagosome-lysosome fusion to protect the septic heart in response to ILC2.Autophagy · 2025Article
- Spatio-temporal processes in autophagosome-lysosome fusion.Medical review (2021) · 2025Review
- Current clinical applications of AAV-mediated gene therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Oxidized protein aggregate lipofuscin impairs cardiomyocyte contractility via late-stage autophagy inhibition.Redox biology · 2025Article
- Function ofInternational journal of molecular sciences · 2025Article
20 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors at 4 institutions in 1 country.
Congwu ChiDivision of Cardiology, Department of Medicine, University of Colorado Auschutz Medical Campus, Aurora, CO 80045.
Andrea LeonardDepartment of Mechanical Engineering, University of Washington, Seattle, WA 98195.
Walter E KnightDivision of Cardiology, Department of Medicine, University of Colorado Auschutz Medical Campus, Aurora, CO 80045.
Kevin M BeussmanDepartment of Mechanical Engineering, University of Washington, Seattle, WA 98195.
Yuanbiao ZhaoDivision of Cardiology, Department of Medicine, University of Colorado Auschutz Medical Campus, Aurora, CO 80045.
Yingqiong CaoDivision of Cardiology, Department of Medicine, University of Colorado Auschutz Medical Campus, Aurora, CO 80045.
Pilar LondonoDivision of Cardiology, Department of Medicine, University of Colorado Auschutz Medical Campus, Aurora, CO 80045.
Ellis AuneDivision of Cardiology, Department of Medicine, University of Colorado Auschutz Medical Campus, Aurora, CO 80045.
Michael A TrembleyAab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14624.
Eric M SmallAab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14624.
Mark Y JeongDivision of Cardiology, Department of Medicine, University of Colorado Auschutz Medical Campus, Aurora, CO 80045.
Lori A WalkerDivision of Cardiology, Department of Medicine, University of Colorado Auschutz Medical Campus, Aurora, CO 80045.
Hongyan XuDepartment of Population Health Sciences, Medical College of Georgia, Augusta University, Augusta, GA 30912.
Nathan J SniadeckiDepartment of Mechanical Engineering, University of Washington, Seattle, WA 98195.ORCID 0000-0001-6960-4492
Matthew R TaylorDivision of Cardiology, Department of Medicine, University of Colorado Auschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0001-9043-0810
Peter M ButtrickDivision of Cardiology, Department of Medicine, University of Colorado Auschutz Medical Campus, Aurora, CO 80045.
Kunhua SongDivision of Cardiology, Department of Medicine, University of Colorado Auschutz Medical Campus, Aurora, CO 80045; kunhua.song@ucdenver.edu.
University of Colorado Anschutz Medical Campus · USCalifornia Institute for Regenerative Medicine · USUniversity of Rochester · USAugusta University · US
Funding
University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0MPOSTGRADUATE TRAINING IN CARDIOVASCULAR RESEARCHT32HL007822 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUTTRICK, PETER N., LEINWAND, LESLIE ANNE · 1996 to 2023
$6.2MTransgenic and Gene Targeting CoreP30AR057212 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI KOCH, PETER J. · 2009 to 2018
$6.2MMechanisms for cell signaling in the control of cardiomyogenesisR01HL133230 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Kunhua Song · 2016 to 2026
$4.2MIntegrins, mechanotransduction, and the maturation of cardiomyocytes derived from induced pluripotent stem cellsF32HL126332 · NHLBI · UNIVERSITY OF WASHINGTON · PI LEONARD, ANDREA B · 2015 to 2017
$164kNCI NIH HHS P30 CA046934NHLBI NIH HHS F32 HL126332NHLBI NIH HHS R01 HL133230NHLBI NIH HHS T32 HL007822NIAMS NIH HHS P30 AR057212
Abstract
Mutations in lysosomal-associated membrane protein 2 (
Indexed as
Membrane FusionAdaptor Proteins, Vesicular TransportAutophagosomesAutophagy-Related ProteinsGene Knockout TechniquesGlycogen Storage Disease Type IIbHumansInduced Pluripotent Stem CellsLysosomal-Associated Membrane Protein 2LysosomesMyocytes, CardiacQa-SNARE ProteinsR-SNARE ProteinsAdaptor Proteins, Vesicular TransportATG14 protein, humanAutophagy-Related ProteinsLAMP2 protein, humanLysosomal-Associated Membrane Protein 2Qa-SNARE ProteinsR-SNARE ProteinsSTX17 protein, humanVAMP8 protein, humanautophagosome–lysosome fusionautophagycardiomyopathyDanon diseaseLAMP-2B
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.