ArticleEnvironment international2019
Exposome-wide association study of semen quality: Systematic discovery of endocrine disrupting chemical biomarkers in fertility require large sample sizes.
Article in Environment international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Design and methodology challenges of environment-wide association studies: A systematic review.Environmental research · 2020Pooled it
- Exploring the exposome and unexplained variance in biological ageing - insights from a longitudinal twin study in adolescence and early adulthood.medRxiv : the preprint server for health sciences · 2026Article
- Using mixture and exposome methods to assess the associations and interactions of chemical biomarkers with semen parameters.Environment international · 2025Article
- Non-Targeted Analysis of Environmental Contaminants and Their Associations with Semen Health Factors in Men from New York City.Environment & health (Washington, D.C.) · 2025Article
- Increasing age in men is negatively associated with sperm quality and DNA integrity but not pregnancy outcomes in assisted reproductive technology.Frontiers in aging · 2025Article
- Exposome Profiling of Environmental Pollutants in Seminal Plasma and Novel Associations with Semen Parameters.Environmental science & technology · 2024Article
- Questionnaire-based exposome-wide association studies for common diseases in the Personalized Environment and Genes Study.Exposome · 2024Article
- Decoding the exposome: data science methodologies and implications in exposome-wide association studies (ExWASs).Exposome · 2024Article
- Exploring the Occurrence of Organic Contaminants in Human Semen through an Innovative LC-HRMS-Based Methodology Suitable for Target and Nontarget Analysis.Environmental science & technology · 2023Article
- Exploring the internal exposome of seminal plasma with semen quality and live birth: A Pilot Study.Systems biology in reproductive medicine · 2023Article
- Endocrine disrupting chemicals and male fertility: from physiological to molecular effects.Frontiers in public health · 2023Review
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- A Factor Analysis Model for Rapid Evaluation of the Semen Quality of Fertile Men in China.Journal of multidisciplinary healthcare · 2022Article
- Study on Influencing Factors of Semen Quality in Fertile Men.Frontiers in physiology · 2022Article
- The health effects of soy: A reference guide for health professionals.Frontiers in nutrition · 2022Review
- Utilizing a Biology-Driven Approach to Map the Exposome in Health and Disease: An Essential Investment to Drive the Next Generation of Environmental Discovery.Environmental health perspectives · 2021Article
- Environmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology.Scientific reports · 2021Article
- UV filters in matched seminal fluid-, urine-, and serum samples from young men.Journal of exposure science & environmental epidemiology · 2021Article
- The Exposome Approach to Decipher the Role of Multiple Environmental and Lifestyle Determinants in Asthma.International journal of environmental research and public health · 2021Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesExposome-wide association studies (EWAS) are a systematic and unbiased way to investigate multiple environmental factors associated with phenotype. We applied EWAS to study semen quality and queried the sample size requirements to detect modest associations in a reproductive cohort. STUDY DESIGN AND
settingWe conducted 1) a multivariate EWAS of 128 endocrine disrupting chemicals (EDCs) from 15 chemical classes measured in urine/serum relative to 7 semen quality endpoints in a prospective cohort study comprising 473 men and 2) estimated the sample size requirements for EWAS etiologic investigations.
resultsNone of the EDCs were associated with semen quality endpoints after adjusting for multiple tests. However, several EDCs (e.g., polychlorinated biphenyl congeners 99, 105, 114, and 167) were associated with raw p < 0.05. In a post hoc statistical power analysis with the observed effect sizes, we determined that EWAS research in male fertility will require a mean sample size of 2696 men (1795-3625) to attain a power of 0.8. The average size of four published studies is 201 men.
conclusionExisting cohort studies with hundreds of participants are underpowered (<0.8) for EWAS-related investigations. Merging cohorts to ensure a sufficient sample size can facilitate the use of EWAS methods for assessing EDC mixtures that impact semen quality.
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Registered trials
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