Trial reportBiological psychiatry2019
Neural Indicators of Anhedonia: Predictors and Mechanisms of Treatment Change in a Randomized Clinical Trial in Early Childhood Depression.
Trial report in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial of PCIT-ED for Preschool Depression
Preschool Based Prevention Targeting Emotion Development in Young Children Facing Adversity
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Great Expectations: A Critical Review of and Suggestions for the Study of Reward Processing as a Cause and Predictor of Depression.Biological psychiatry · 2021Pooled it
- The thrill of victory: Savoring positive affect, psychophysiological reward processing, and symptoms of depression.Emotion (Washington, D.C.) · 2022Trial
- Preschool-Onset Major Depressive Disorder is Characterized by Electrocortical Deficits in Processing Pleasant Emotional Pictures.Journal of abnormal child psychology · 2020Trial
- Asking Preadolescents About Suicide Is Not Associated With Increased Suicidal Thoughts.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Association Between Early Childhood P300 Deficits and Risk for Preadolescence Depressive Disorder Mediated by Responsiveness to PCIT-ED Treatment.Research on child and adolescent psychopathology · 2025Article
- Preschool-Onset Major Depressive Disorder as a Strong Predictor of Suicidal Ideation and Behaviors Into Preadolescence.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
- Reduced neural responses to reward reflect anhedonia and inattention: an ERP study.Scientific reports · 2022Article
- The reward positivity shows increased amplitude and decreased latency with increasing age in early childhood.Developmental science · 2022Article
- Predicting depression among rural and urban disabled elderly in China using a random forest classifier.BMC psychiatry · 2022Article
- Identifying intervention strategies for preventing the mental health consequences of childhood adversity: A modified Delphi study.Development and psychopathology · 2021Article
- Increased self-reported reward responsiveness predicts better response to cognitive behavioral therapy for youth with anxiety.Journal of anxiety disorders · 2021Article
- Reward-Related Neural Predictors and Mechanisms of Symptom Change in Cognitive Behavioral Therapy for Depressed Adolescent Girls.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Developmental trajectories to reduced activation of positive valence systems: A review of biological and environmental contributions.Developmental cognitive neuroscience · 2020Review
- Neurobiology and the Hierarchical Taxonomy of Psychopathology: progress toward ontogenetically informed and clinically useful nosology .Dialogues in clinical neuroscience · 2020Review
- Mapping infant neurodevelopmental precursors of mental disorders: How synthetic cohorts & computational approaches can be used to enhance prediction of early childhood psychopathology.Behaviour research and therapy · 2019Article
- Preschool Depression: a Diagnostic Reality.Current psychiatry reports · 2019Review
- Reduced Reward Responsiveness Predicts Change in Depressive Symptoms in Anxious Children and Adolescents Following Treatment.Journal of child and adolescent psychopharmacology · 2019Article
- Article
Corrections and comments
- Retraction · 2020-08-25Error in Data · Error in Methods · Error in Results and/or Conclusions ·
- Retracted
Authors and funding
7 authors.
Funding
Abstract
backgroundEarly childhood depression is associated with anhedonia and reduced event-related potential (ERP) responses to rewarding or pleasant stimuli. Whether these neural measures are indicators of target engagement or treatment outcome is not yet known.
methodsWe measured ERP responses to win and loss feedback in a guessing task and to pleasant versus neutral pictures in young (4.0-6.9 years of age) depressed children before and after randomization to either 18 weeks of Parent-Child Interaction Therapy-Emotion Development (PCIT-ED) treatment or waitlist (WL) control condition.
resultsAnalyses included reward positivity (RewP) data from 118 children randomized to PCIT-ED treatment (n = 60) or WL control condition (n = 58) at baseline and late positive potential (LPP) data from 99 children (44 PCIT-ED treatment vs. 55 WL control condition) at baseline. Children in the PCIT-ED group showed a greater reduction in anhedonia (F
conclusionsThe ERP reward response improved in young children with depression during a treatment designed to enhance emotion development, providing evidence of target engagement of the neural systems associated with reward. Further, greater baseline LPP responses to positive pictures were associated with a greater reduction in depression, suggesting that this ERP measure can predict which children are most likely to respond to treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.