Evidence map›Paper›PMID 30583798›Full record

ArticleAmerican journal of human genetics2019

GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology.

Jonas Bovijn, Leigh Jackson, Jenny Censin, Chia-Yen Chen, Triin Laisk, Samantha Laber, Teresa Ferreira, Sara L Pulit, Craig A Glastonbury, Jordan W Smoller and 12 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 5 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 5 syntheses or guidelines pooled it, 114 citations in OpenAlex.

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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 4 countries.

Jonas BovijnBig Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK. Electronic address: jbovijn@well.ox.ac.uk.
Leigh JacksonInstitute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Jenny CensinBig Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.
Chia-Yen ChenAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Triin LaiskEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia; Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, Tartu 50406, Estonia.
Samantha LaberBig Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.
Teresa FerreiraBig Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK.
Sara L PulitBig Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA; Department of Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
Craig A GlastonburyBig Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK.
Jordan W SmollerPsychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Jamie W HarrisonGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Katherine S RuthGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Robin N BeaumontGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Samuel E JonesGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Jessica TyrrellGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Andrew R WoodGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Michael N WeedonGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Reedik MägiEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.
Benjamin NealeAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Cecilia M LindgrenBig Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.
Anna MurrayGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK. Electronic address: a.murray@exeter.ac.uk.
Michael V HolmesNational Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, Old Road, Oxford OX3 7LE, UK; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, Big Data Institute Building, Roosevelt Drive, University of Oxford, Oxford OX3 7LF, UK; Medical Research Council Population Health Research Unit at the University of Oxford, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
University of Exeter · GBCentre for Human Genetics · GBMassachusetts General Hospital · USBroad Institute · USUniversity of Oxford · GBUniversity of Tartu · EENational Institute for Health Research · GB

Funding

The Genetic Determinants of Human GNRH DeficiencyP50HD028138 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI SEMINARA, STEPHANIE BETH · 2014 to 2020
$12.9M
British Heart Foundation FS/18/23/33512Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NICHD NIH HHS P50 HD028138
6 · The paper itself

Abstract

Erectile dysfunction (ED) is a common condition affecting more than 20% of men over 60 years, yet little is known about its genetic architecture. We performed a genome-wide association study of ED in 6,175 case subjects among 223,805 European men and identified one locus at 6q16.3 (lead variant rs57989773, OR 1.20 per C-allele; p = 5.71 × 10

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyAllelesBasic Helix-Loop-Helix ProteinsChromosomes, Human, Pair 6Computer SimulationDiabetes Mellitus, Type 2Erectile DysfunctionEuropeHumansHypothalamusMaleRepressor ProteinsBasic Helix-Loop-Helix ProteinsRepressor ProteinsSIM1 protein, humandiabeteserectile dysfunctiongenome-wide associationGWASimpotencemendelian randomisationMendelian randomizationSIM1UK biobank

Identifiers

PMID30583798
PMCPMC6323625
OpenAlexW2794222554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.